Degussa Aktiengesellschaft

Forschungszentrum Juelich Gmbh

Bettina Moeckel

Walter Pfefferle

Caroline Kreutzer

Brigitte Bathe

Thomas Hermann

Georg Thierbach

Michael Binder

Mike Farwick

Klaus Huthmacher

Dieter Greissinger

Joern Kalinowski

Alfred Puehler

Christian Rueckert

Achim Marx

Stephan Hans

Natalie Schischka

Nicole Dusch

Christine Bastuck

Hermann Sahm

Lothar Eggeling

Stefan Hans

Mike Garwick

Isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the lysR2 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.

Nucleotide sequences for encoding of the lysR2-gene

The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity.

Nucleotide sequences coding for the LuxR gene

The present invention provides nucleotide sequences from Coryneform bacteria which code for the PtsI protein and a process for the fermentative preparation of amino acids using bacteria in which the ptsI gene is enhanced.

Nucleotide sequences coding for the PtsI protein

The invention relates to polynucleotides corresponding to the ccpA2 gene and which encode a CcpA2 catabolite control protein, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having CcpA2 catabolite control activity.

Nucleotide sequences which code for the ccpA2 gene

The present invention provides isolated polynucleotides containing a polynucleotide sequence which is:

Attenuated CCPA1 modified bacterial cell and its use for the preparation of L-amino acids

Isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of

An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of

Nucleotide sequence which code for the metH gene

Isolated polynucleotide from Corynebacterium encoding a homocysteine methyltransferase

An isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of

Nucleotide sequences which code for the rpsL gene

The present invention relates to polynucleotides corresponding to the lysR1 gene and which encode a LysR1 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR1 transcriptional regulator activity.

Nucleotide sequences coding for the 1ysR1 gene

The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity. The invention also relates to isolating the luxR gene and which encode a LuxR transcriptional activator from

Nucleotide sequences coding for the luxR gene

Nucleotide sequences coding for the ccpA1 gene

The present invention relates to polynucleotides corresponding to the lysR3 gene and which encode a LysR3 transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LysR3 transcriptional regulator activity.

Nucleotide sequences which code for the lysR3 gene

The present invention relates to isolated polynucleotides which encode proteins with O-acetylhomoserine sulfhydrylase, vectors and cells containing the polynucleotides as well as methods of preparing L-amino acids.

Nucleotide sequences which code for the metY gene

The present invention relates to polynucleotides corresponding to the rpoB gene and which encode the &bgr;-subunit of RNA polymerase B, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having activity of the &bgr;-subunit of RNA polymerase B.

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Duesseldorf, Germany

Bettina Moeckel