Albert Einstein College of Medicine

Duke University

Betsy C Herold

William R Jacobs, Jr

Christopher Petro

Pablo A Gonzalez-Munoz

Pablo A Gonzalez Munoz

Natalia Cheshenko

Steven Craig Almo

Garnett Kelsoe

William R Jacobs

Masayuki Kuraoka

Jeffrey Bryan Bonanno

Clare Burn Aschner

Joseph Dardick

Kayla A Weiss

Clare Burn

Provided are antibodies and antigen-binding fragments which bind to herpes simplex virus-2 (HSV-2), methods of use employing the antibodies and/or antigen-binding fragments, and pharmaceutical compositions comprising the antibodies and/or antigen-binding fragments.

Monoclonal antibodies for prevention and treatment of herpes simplex viral infections

Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, compositions and vaccines comprising such, and methods of use thereof are each provided.

HSV-2-delta-gD vaccines and methods for their production and use

Methods of vaccinating, immunizing and/or treating a subject against a herpes simplex virus infection or a disease caused by a herpes simplex virus infection comprise administering to the subject an effective amount of a HSV-2 single-cycle virus and an effective amount of a recombinant HSV-2 glycoprotein D, wherein the HSV-2 single-cycle virus comprises HSV-2 having a deletion of glycoprotein D-encoding gene in the genome and the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D on a lipid bilayer of the HSV-2.

Methods of using HSV-2 single cycle virus delta-gD and HSV-2 recombinant glycoprotein D

Methods and compositions are provided for inhibiting or treating a viral infection in a subject using cell-impermeable inhibitors of Akt, scramblase and/or a phosphatidylserine.

Prevention and treatment of viral infections

Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.

Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors

Methods for passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such.

Passive transfer of immunity using recombinant herpes simplex virus 2 (HSV-2) vaccine vectors

Methods and compositions are provided for inhibiting or treating a herpesvirus infection in a subject using inhibitors of mammalian Akt.

Growing community of inventors

Rowayton, CT, United States of America

Betsy C Herold