Systemix, Inc.

Beth Louis Hill

Benjamin P Chen

Elen Rozler

Paul J Simmons

This invention provides a novel antibody, designated .alpha.EM10, and a hybridoma cell line that produces the .alpha.EM10 antibody. Also provided are methods to obtain compositions enriched for hematopoietic stem cells. The methods employ a separation technique utilizing antibodies (.alpha.EM10) specific for a unique cell marker (EM10) that is expressed on stem and progenitor cells, while being less accessible or absent on more mature cells. Further provided are cell compositions enriched for EM10+ cells.

Methods of obtaining compositions enriched for hematopoietic stem cells,

A method for obtaining human hematopoietic stem cells is provided by enrichment for stem cells using a novel stem cell marker. Compositions enriched for stem cells are obtained using novel antibody HCC-1 which is specific for a CD59 epitope highly accessible on stem cells, and less accessible or absent on mature cells. The enriched population of cells derived from these methods are also provided.

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Mountain View, CA, United States of America

Beth Louis Hill