Eli Lilly and Company

Beth Ann Strifler

Kristine Kay Kikly

Derrick Ryan Witcher

Catherine Brautigam Beidler

Richard Todd Pickard

John D Sharp

Ruth M Kramer

Xue-Chiou C Choiu

Wolfgang Glaesner

Christopher Carl Frye

Radmila Micanovic

John Michael Beals

Shun Li

Jeffrey Streetman Boyles

Radhakrishnan Rathnachalam

Sudhakar Reddy Chintharlapalli

Jing Shang

Catherine Brautigam Beilder

Derek Ryan Witcher

Antibodies are provided that specifically bind seven human ELR+ CXC chemokines. The antibodies of the invention are useful for treating various inflammatory/autoimmune diseases, such as inflammatory bowel disease (IBD), plaque psoriasis, and palmoplantar pustulosis; and cancer, such as renal cancer or ovarian cancer.

Pan-ELR+ CXC chemokine antibodies

Antibodies are provided that specifically bind seven human ELRCXC chemokines. The antibodies of the invention are useful for treating various inflammatory/autoimmune diseases, such as inflammatory bowel disease (IBD), plaque psoriasis, and palmoplantar pustulosis; and cancer, such as renal cancer or ovarian cancer.

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Pan-ELR+ CXC Chemokine Antibodies

The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.

Muteins of fibroblast growth factor 21

The invention provides a novel phospholipase A,enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.

Human phospholipase A2 and related nucleic acid compounds

The invention provides a novel phospholipase A,enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic add cascade.

The invention provides a novel phospholipase A.sub.2 enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.

Human phospholipase A.sub.2 and related nucleic acid compounds

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Brownsburg, IN, United States of America

Beth Ann Strifler