Other

Cook Incorporated

William Cook, Europe A/s

Beth Ann Kirts

Zaza Alexandrovich Kavteladze

Aleksandr P Korshok

Palle M Hansen

Andrej A Kadnikov

Brian C Case

Thomas A Osborne

Edward J Morris

Thomas O McNamara

Prosthetic valves for regulating fluid flow are provided. The valves have at least one leaflet that includes a plurality of pores that allow a quantity of retrograde flow to pass through the leaflet when the valve is in a closed configuration.

Prosthetic valve with pores

A prosthetic device for sustaining a vessel or hollow organ lumen (a stent) having a tubular wire frame ( ) with rows of elongate cells ( ) each having a larger axis and a smaller axis. The cells are arranged with the larger axis in the circumferential direction of the frame ( ) and the smaller axis parallel to the axial direction thereof. Each cell is formed by two U-shaped wire sections, and in a plane perpendicular to the longitudinal axis one of the branches of the U-shaped wire sections in one row form together a closed ring shape ( ) which provides the frame ( ) with large radial stiffness. In the axial direction the frame ( ) has only low stiffness so that it easily conforms to the vascular wall even if this deforms due to external loads. The interconnection between the cells ( ) may be flexible.

Implantable, self-expanding prosthetic device

A prosthetic device for sustaining a vessel or hollow organ lumen (a stent) have a tubular wire frame ( ) with rows of elongate cells ( ) each having a larger axis and a smaller axis. The cells are arranged with the larger axis in the circumferential direction of the frame ( ) and the smaller axis parallel to the axial direction thereof. Each cell is formed by two U-shaped wire sections, and in a plane perpendicular to the longitudinal axis one of the branches of the U-shaped wire sections in one row form together a closed ring shape ( ) which provides the frame ( ) with large radial stiffness. In the axial direction the frame ( ) has only low stiffness so that it easily conforms to the vascular wall even if this deforms due to external loads. The interconnection between the cells ( ) may be flexible.

Implantable self expanding prosthetic device

A prosthetic device for sustaining a vessel or hollow organ lumen (a stent) has a tubular wire frame ( ) with rows of elongate cells ( ) having a larger axis and a smaller axis. The cells are arranged with the larger axis in the circumferential direction of the frame ( ) and the smaller axis parallel to the axial direction thereof. Each cell is formed by two U-shaped wire sections, and in a plane perpendicular to the longitudinal axis one of the branches of the U-shaped wire sections in one row form together a closed ring shape ( ) which provides the frame ( ) with large radial stiffness. In the axial direction the frame ( ) has only low stiffness so that it easily conforms to the vascular wall even if this deforms due to external loads. The interconnection between the cells ( ) may be flexible.

A preformed anchoring wire guide (,) for medical procedures such as renal angioplasty. The wire guide (,) is comprised of a superelastic memory alloy mandril (,), such as a nickel-titanium alloy, and includes a preformed bend (,) having an angle (,) with respect to the longitudinal axis (,) that corresponds with the takeoff angle of the renal artery (,) relative to the aorta (,). This preformed bend (,) allows easier access to the ostium (,) of the renal artery (,) and allows the distal portion (,) of the wire guide to anchor within the artery (,) and resist dislodgement and deformation, thereby improving trackability of a balloon angioplasty catheter (,), reducing the need for a guiding catheter, and reducing the likelihood of vessel damage or thrombus shear due to forces that are normally exerted against the wall of the vessel (,) by a standard wire guide. The wire guide has a tapered distal portion (,) over which a spring coil wire (,) is attached to provide radiopacity and safety to the vasculature. The distal portion (,) of the wire guide is flexible and is further made atraumatic by the addition of a hook-shaped or &ldquo;J&rdquo; tip (,). Additionally, the nickel-titanium alloy mandril is cold-worked in its austenitic phase at preformed bend (,) by overstressing the wire in a fixture, thereby shifting at least part of the crystalline structure to martensite within the region of the preformed bend (,).

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Bloomington, IN, United States of America

Beth Ann Kirts