American Cyanamid Company

Beth A Rasmussen

Yakov Gluzman

Francis P Tally

This invention is directed to the elucidation of DNA sequences encoding Class B beta-lactamase enzymes from Bacteroides fragilis and the amino acid sequences of those enzymes. This invention is also directed to screening methods for identifying antibiotics which are resistant to such beta-lactamase enzymes or for identifying compounds which inactivate such beta-lactamase enzymes.

DNA Sequences and amino acid sequences of class B beta-lactamase enzymes

Methods for screening class B beta-lactamase enzymes from Bacteroides

This invention relates to a purified isolated DNA fragment of Bacteroides fragilis comprising a sequence for an operon containing two genes designated rprX and rprY. These genes encode two signal transducing regulatory proteins designated RprX and RprY. This invention further relates to the proteins RprX and RprY encoded by the operon. RprX and RprY affect the normal regulation of OmpF by OmpR and EnvZ.

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Nyack, NY, United States of America

Beth A Rasmussen