Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Assistance Publique-hopitaux De Paris

Sorbonne Université

UniversitÉ De Paris

Universite Paris Cité

Université D'auvergne Clermont 1

Laboratories Cyclopharma

Sanofi

Sanofi-aventis

Université Clermont Auvergne

Laboratoires Cyclopharma

Bertrand Tavitian

Mickaël Tanter

Mathieu Pernot

Isabelle Texier-Nogues

Frank Marguet

Thomas Rooney

Vincent Dive

Vittorio De Franciscis

Renaud Maroy

Eric Doris

Laura Cerchia

Fabrice Beau

Frédéric Duconge

Jean-Michel Chezal

Frederic Dolle

André Menez

Jesus Benavides

Jean-Claude Madelmont

Bertrand Czarny

Elisabeth Miot-Noirault

Raphael Boisgard

Joël Cotton

Edmond Gravel

Thomas Viel

Anikitos Garofalakis

Vincent Frouin

Jean Provost

Mailyn Perez-liva

Joaquin Lopez Herraiz

Janine Papon

Nicole Moins

Aurelie Maisonial

Raphaël Boisgard

Juliette Merian

Nicolas Mackiewicz

Bertrand Kuhnast

Cyrille Thominiaux

Domenico Libri

Frédéric Dolle

Bertand Kuhnast

Hervé Boutin

Annelaure Damont

Luc Rivron

Philippe Hantraye

Marie-Noelle Castel

Herve Boutin

Aurélie Maisonial

Marie-Noëlle Castel

The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a γ-ray, and c) determining the at least one property of the object based on the first data and the second data.

Method for determining a property of an object and associated device

Super resolution in positron emission tomography imaging using ultrafast ultrasound imaging

The invention relates to polymerized micelles of size inferior to 100 nm for in vivo diagnosis, in particular of cancer. The polymerized micelles of the invention comprise a diagnostic agent and an amphiphilic polymer obtainable by the polymerization of an amphiphilic monomer, said monomer comprising: a lipophilic chain comprising a polymerizable vinylic or diacetylenic group, and a hydrophilic head comprising a polyoxyethylene or polyoxypropylene chain. The invention finds application in the pharmaceutical field, in particular.

Polymerized micelles for diagnosis

The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.

Formulas for diagnosing and treating hormone-dependent cancers and cancers of the organs responsible for steroid hormone synthesis

The present invention relates to the compound of formula (I):   The present invention also relates to pharmaceutical compositions comprising them and to their use in diagnosis, in particular with SPECT or PET imaging and in therapy of melanoma via targeted radionuclide therapy.

Labelled analogues of halobenzamides as multimodal radiopharmaceuticals and their precursors

A method provides for estimating the concentration of a tracer in a tissue structure assembly including at least one tissue structure, from a measurement image of the tracer concentration in said tissue structure assembly, which is obtained by an imaging apparatus, wherein said image includes at least one space domain inside which the tracer concentration is homogenous and at least one region of interest in which the tracer concentration is measured. The method includes: determining a geometric transfer matrix having coefficients representative of the contribution of the space domains in the measurement of the tracer concentration in the regions of interest; optimizing the coefficient of the geometric transfer matrix by defining the best regions of interest in terms of errors in order to measure the tracer concentration, the definition of the regions of interest being carried out according to an iterative loop that includes the following steps upon each iteration: modifying the regions of interest, and calculating the coefficients of the geometric transfer matrix from the modified regions of interest; selecting an optimized geometric transfer matrix among the calculated geometric transfer matrices; and estimating the tracer concentration from the optimized geometric transfer matrix.

Method for estimating the concentration of a tracer in a tissue structure assembly, and corresponding storage medium and device

The present invention relates to a method of segmenting a starting image or sequence of tridimensional images for obtaining a tridimensional segmentation image comprising a partition into regions of interest, said image or sequence of images comprising measurements, for each voxel and in the course of n time intervals (n&#x2267;1), of the real evolution of a signal representative of at least one variable of said image or sequence, which comprises essentially:

Method of segmentation of a sequence of three-dimensional images, in particular in pharmaco-imagerie

The invention relates to an amplification-free method of screening groups of radioactive molecules, comprising at least the following steps: (1) the group of molecules is administered to at least one animal; (2) at least one of the animals is slaughtered and the tissue distribution of the radioactivity of the molecules administered is analyzed in vivo; (3) sections of tissue or organs in which a radioactivity signal is detected are selected; (4) radioactive fractions from the sections of tissue or organs are isolated using suitable techniques such as chromatography and/or extraction techniques; and (5) the molecule(s) from the radioactive fractions obtained in step 4 are characterized using suitable analysis techniques such as chromatography and/or mass spectrometry.

Method of screening groups of radioactive molecules and applications thereof

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Paris, France

Bertrand Tavitian