Lltech Management

Bertrand Le Conte Chrestien De Poly

Albert Claude Boccara

Fabrice Harms

A device for three-dimensional imaging by full-field interferential microscopy of a volumic and scattering sample includes an imaging interferometer of variable magnification, allowing for the acquisition of at least one first and one second interferometric images resulting from the interference of a reference wave obtained by reflection of the incident wave on a reference mirror and an object wave obtained by backscattering of the incident wave by a slice of the sample at a given depth of the sample. The invention also relates to a processing unit that processes the interferometric images, a unit for axially displacing the interferometer relative to the sample for the acquisition of tomographic images for slices at different depths of the sample, and a unit for varying the magnification of the imaging interferometer for the acquisition of interferometric images of a slice for different magnification values.

Method and device for high resolution full field interference microscopy

According to a first aspect, the invention relates to a multimodal optical sectioning microscope () for full-field imaging of a volumic and scattering sample comprising: &#x2014;a full-field OCT system for providing an image of a first section in depth of the sample comprising an illumination sub-system () and a full-field imaging interferometer with a detection sub system () and an optical conjugation device for optically conjugating the sample and said detection sub system, wherein said optical conjugation device comprises a microscope objective (), &#x2014;a supplementary full-field optical sectioning imaging system for providing a fluorescent image of a second section in depth of said sample comprising a structured illumination microscope with an illumination sub system (), means () for generating at the focal plane of said microscope objective of said full-field imaging interferometer a variable spatial pattern illumination and a detection sub system (), optically conjugated with said focal plane of the microscope objective.

Optical tissue sectioning using full field optical coherence tomography

The invention relates to an incoherent light full field interference microscopy device for the imaging of a volumetric scattering sample (). The device comprises an interference device () between a reference wave (), produced by reflection of an incident wave by a reflective surface () of a reference arm of the interference device, and an object wave () produced by backscattering of the incident wave by a slice of the sample, an acquisition device () for at least a first interference signal and at least a second interference signal resulting from the interference of the reference and object waves, the at least two interference signals having a phase difference, an processing unit () for calculating an image of the slice of the sample, based on said interference signals. The interference device also comprises an optical element () for modifying the phase of the wavefront, and the microscopy device comprises a control unit () for the optical element, linked to the processing unit (), the optical phase modification element being controlled by optimizing a statistical parameter of at least a part of the image calculated by the processing unit.

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Paris, France

Bertrand Le Conte Chrestien De Poly