Adolor Corporation

Yumanity Therapeutics, Inc.

Bertrand Le Bourdonnec

Roland Ellwood Dolle

Guo-Hua Chu

Allan James Goodman

Matthew C Lucas

Daniel Tardiff

Bhaumik Pandya

Kenneth Rhodes

Robert Scannevin

Jeff Piotrowski

Rebecca Aron

Parcharee Tivitmahaisoon

Iwona Wrona

Kerem Ozboya

Benjamin Vincent

Eric Solis

Chee-Yeun Chung

Minghua Gu

Paul Anson Tuthill, Sr

Christopher William Ajello

Roland E Dolle, Iii

Christopher W Ajello

Jean Q Zhou

Lara K Leister

The invention provides compositions and methods for treating neurological disorders, such as amyotrophic lateral sclerosis, frontotemporal degeneration, and Alzheimer's disease, among others. Using the compositions and methods described herein, a patient having a neurological disorder, such as a neurological disorder associated with TAR-DNA binding protein (TDP)-43 aggregation, may be administered an inhibitor of cytochrome P450 (CYP450) isoform 51A1 (CYP51A1), also referred to herein as lanosterol 14-alpha demethylase, so as to treat an underlying etiology of the disorder and/or to alleviate one or more symptoms of the disease. The inhibitor of CYP51A1 may be a small molecule, anti-CYP51A1 antibody or antigen-binding fragment thereof, or a compound, such as an interfering RNA molecule, that attenuates CYP51A1 expression. Patients that may be treated using the compositions and methods described herein include those that express a mutant TDP-43 isoform containing a mutation associated with TDP-43-promoted aggregation and toxicity.

Compositions and methods for the treatment and prevention of neurological disorders

The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Methods for the treatment of neurological disorders

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Compounds and uses thereof

Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.

Opioid antagonists

3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as antagonists of opioid receptors.

Substituted piperidine compounds and methods of their use

Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as antagonists of opioid receptors.

Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the &#x3b4; opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other &#x3b4; opioid receptor-mediated conditions.

Spirocyclic heterocyclic derivatives and methods of their use

This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs.

Beloxepin and analogs for the treatment of pain

Certain 4-aryl-piperidine compounds, including N-substituted 9&#x3b2;-substituted-5-(3-substituted-phenyl)morphans and N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines, pharmaceutical compositions, and methods of their use, inter alia, as opioid antagonists are disclosed.

Growing community of inventors

East Fallowfield, PA, United States of America

Bertrand Le Bourdonnec