Agence Nationale De Valorisation De La Recherche (anvar)

Produits Chimiques Ugine Kuhlmann

Bertrand Castro

Pierre Corvol

Daniel H Balde

Karoly Szabo

Genevieve Evin

Joel Menard

Heterocyclic compounds of the general formula: ##STR1## wherein: R.sub.1 represents alkyl, haloalkyl, alkenyl, haloalkenyl, arylalkyl, arylhaloalkyl, cycloalkyl, halocycloalkyl, aryl, haloaryl, alkoxyalkyl or haloalkoxyalkyl;

N-Acylated heterocycles and herbicidal-antidote uses thereof

The novel derivatives of pepstatin have the general formula (I) below in which X, Y and Z, are identical or different, and each represent an amino-acid selected from arginine, glutamic acid, aspartic acid, lysine, histidine and valine, the carboxyl function of the terminal amino-acid being esterifiable. The indices a, b and c are each equal to zero or 1, the sum a+b+c being equal to 1, 2 or 3. The invention also includes the water soluble salts and their preparation, and the compositions containing them. ##STR1## These novel products are particularly useful in the diagnosis and treatment of arterial hypertension due to the action of renine.

Novel derivatives of pepstatin, their preparation and compositions

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Messein, France

Bertrand Castro