Sanofi-synthelabo

Sanofi-aventis

Institut Pasteur and Centre National De La Recherche Scientifique

Sanofi-stnth{dot Over (e)}labo

Bertrand Castro

Jean-Robert Dormoy

Alain Rabion

Aldo Previero

Mouad Alami

Andr&eacute; Bousquet

Jean Saint-Germain

H&eacute;l&egrave;ne Mattras

Eric Riguet

G&eacute;rard Cahiez

Dino Nisato

Alain Heymes

Attila Supic

Istv&aacute;n M&eacute;sz&aacute;ros

Michel Biard

Zolt&aacute;n Makovi

Attila Kis-Tam&aacute;s

Csaba Husz&aacute;r

Attila N&eacute;meth

P&eacute;ter Aranyosi

K&aacute;roly Gy&uuml;re

Katalin Dubovszki

Lajosn&eacute; P&aacute;li

Antal Gaj&aacute;ry

Endre Koll&aacute;r

&Aacute;gnes Kunsztn&eacute; K&aacute;r&aacute;sz

Erzs&eacute;bet Bogn&aacute;r

Zsuzsanna N&aacute;d

M&aacute;ria Bakonyi

Zsuzsanna Csetrin&eacute; H&aacute;ri

Marianna Csat&aacute;rin&eacute; Nagy

Patrick Jouin

Ilona Dervalicsn&eacute; Zr&iacute;nyi

Levent&eacute;n&eacute; Moln&aacute;r

The invention relates to lower-alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid derivatives, and to processes for preparing the same.

Alkyl esters of 3-(3,4-dihalophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates

Novel orthorombic polymorph of clopidogrel hydrogen sulfate or hydrogen sulfate of methyl (&plus;)-(S)-&agr;-(2-chlorophenyl)-4,5,6,7-tetrahydrothieno&lsqb;3,2-c&rsqb;pyridine-5-acetate and a process for its preparation

Polymorphic form of clopidogrel hydrogen sulphate

Alkyl esters of 3-(3,4-dihalogenophenyl)-2,6-dioxopiperidine-3-propionic acid of use as intermediates

This invention relates to 3-(3-phenyl-2,6-dioxopiperidin-3-yl) propionamide derivatives, and to processes for preparing the same.

3-phenyl-2,6-dioxopiperidin-3-ylpropionamide derivatives and method for preparing same

Novel orthorombic polymorph of clopidogrel hydrogen sulfate or hydrogen sulfate of methyl (&plus;)-(S)-&agr;-(2-chlorophenyl)-4,5,6,7-tetrahydrothieno&lsqb;3,2-c&rsqb;pyridine-5-acetate and a process for its preparation.

Polymorphic clopidogrel hydrogenesulphate form

Method for preparing 4-methyl-biphenyl derivatives

The subject-matter of the invention is a process for the preparation of o-(p-tolyl)benzonitrile, characterized in that an o-halobenzonitrile is treated with a p-tolylmagnesium halide in the presence of a manganous salt and of a cocatalyst comprising a transition metal.

Process for the preparation of a cyanobiphenyl

This invention relates to 3-(3-phenyl-2,6-dioxopiperidin-3-yl)propionamide derivatives, and to processes for preparing the same.

3-phenyl-2, 6-dioxopiperidin-3-yl propionamide derivatives and method for preparing same

Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C,alkyl group, or C,aralkyl group or phenyl group, characterised in that: a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C,alkoxy group or hydroxyl group and the resulting compound of formula (II) is transformed in the presence of an oxidising agent in a reaction medium with pH above 7, into the compound of formula (I), or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts. Thus a process for the preparation of intermediates useful in synthesis of angiotensin II antagonists is disclosed.

Process for the preparation of 1,3-diaza-spiro (4.4) non-1-en-4-one derivatives and 1-cyano-1-acylamino-cyclopentane intermediates

A process for the preparation of &lsqb;2-(2-thienyl)-ethylamino&rsqb;-(2-halogenophenyl)-acetonitriles of general formula (I) starting from 2-(2-thienyl)-ethyl-amine, alkalicyanide and o-halogeno-benzaldehyde. Compounds of general formula (I) are valuable intermediates.

Intermediates and process for the preparation thereof

The present invention relates to a process for the preparation of 4&prime;-bromomethyl-biphenyl derivatives of the formula:

Method for preparing bromomenthyl-biphenyl derivatives

Method for preparing 2-thienylethylamine derivatives

The process described makes it possible to obtain optically pure 4-amino-3-hydroxycarboxylic acids by means of a series of stereoselective steps. The starting material is an alpha-amino acid in the L or D configuration, with which Meldrum's acid is reacted. The resulting pyrrolone derivative is reduced prior to opening of the pyrrolidine ring. The invention also relates to the new products obtained by the said process and to the pyrrolone derivatives obtained as intermediates.

Process for the stereospecific synthesis of optically pure

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Saint Aunes, France

Bertrand Castro