Otto-von-guericke-universität Magdeburg

Otto-von-guericke-universität

Leibniz-institut Fuer Neurobiologie Magdeburg

Leibniz-institut Für Neurobiologie

Leibniz-institut Für Neurobiologie Magdeburg

Hahn-schickard-gesellschaft Fur Angewandte Forschung E.v.

Bertram Schmidt

Frank Ohl

Michael Lippert

Martin Deckert

Armin Dadgar

Sören Hirsch

Axel Dipl-Phys Schumacher

Mani Dr Rer Nat Dipl-Ing Alavi

Hermann Dipl-Phys Scheithauer

The invention relates to an image-capturing device for the miniaturized near-field image capture of biological tissue, in particular for the imaging of genetic indicators. The image-capturing device comprises at least one digital image sensor and an objective lens in the form of a rod-shaped gradient index lens (GRIN), which objective lens is coupled to the digital image sensor for image capture. The objective lens is connected to the digital image sensor to from a monolithic, fixed assembly. There is no mechanical separating interface between the objective lens and the digital image sensor by means of which the digital image sensor can be separated from the objective lens by the user. The invention further relates to a system for the miniaturized near-field image capture of biological tissue, said system comprising an image-capturing device of this type and an evaluation device connected to the image-capturing device.

Image-capturing device, system and method for capturing images

A micro-electrode array () comprising a flexible substrate () and a multiplicity of electrodes () for electrically measuring neural activity is described. The electrodes () are arranged on the substrate (), project from the plane of the substrate () and have a core (). A plurality of measurement lines () that are electrically insulated from one another are arranged around the core (). Adjacent to the end surface () of the core (), at the end of the electrodes () there are a plurality of electrode surfaces () arranged in a manner distributed spatially around the end surface (), said electrode surfaces in each case being electrically conductively connected to an associated measurement line (). The micro-electrode array () is passivated with a polymer-containing material, such as e.g. polyimide, such that only the electrodes () electrically contact neural tissue with their electrode surfaces (, E, E).

Micro-electrode array and method for producing a micro-electrode array

The invention relates to a method for obtaining brain wave data using a microelectrode array, comprising a plurality of electrodes for electrically measuring brain waves and an integrated optical stimulation unit for stimulating brain regions by means of optical signals, wherein the stimulation unit has one or more electrical light sources, and wherein the method includes stimulating neurons of the brain via optical signals produced by the light sources, recording a response of the neurons to the stimulation via the electrodes, unambiguously assigning the recorded response to individual optical stimulation signals provided by the light source, and determining an unambiguous correlation between the optical stimulation signals and resulting brain waves measured by the electrodes.

Microelectrode array for an electrocorticogram

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Villingen-Schwenningen, Germany

Bertram Schmidt