Astra Lakemedel Aktiebolag

Astra Pharmaceutical Products, Inc.

Bertil Ake Ekstrom

Ulf E Forsgren

Berndt Olof Sjoberg

Peter Bamberg

Berndt O Sjoberg

Sven Erik Dahlen

Odon Kalman Kovacs

Olof Harald Sjoberg

An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.

Antibacterial combination of penicillin and cephalosporin

Antibiotic combinations of penicillins

Synergistic penicillin-cephalosporin compositions and methods

Penicillin composition

New esters of amidinopenicillanic acids of the formula ##STR1## wherein each of R.sup.1 and R.sup.2, which are the same or different, is a saturated or unsaturated alkyl group, a cycloalkyl, or cycloalkyl-alkyl group, or wherein R.sup.1 and R.sup.2, together with the adjacent nitrogen atom, form a heterocyclic ring system; R.sup.3 is the radical ##STR2## in which radicals R.sup.4 is an alkyl, phenyl, or substituted phenyl; and R.sup.5 is hydrogen or methyl, useful as active ingredients in pharmaceutical preparation and methods for the treatment of infectious diseases.

Esters of amidinopenicillanic acids, pharmaceutical preparations and

New carbonate esters of penicillins, having the formula ##EQU1## wherein R.sup. 1 is substituted or unsubstituted alkyl, alkenyl, aryl, aryloxy or heterocyclic group, R.sup.2 is ##EQU2## in which formula R.sup.3 is H or -CH.sub.3,

Carbonate esters of penicillins and compositions and methods for

New esters of .alpha.-aminopenicillins having the formula ##EQU1## wherein R is C.sub.2 -C.sub.7 alkyl; WHEREIN R.sup.2 = H or OH, R.sup.3 = H or halogen; ##SPC1## Wherein R.sup.1 is ##EQU2## or --Ch.sub.2 NHCOO--R.sup.4 wherein R.sup.4 = C.sub.1 -C.sub.4 alkyl; R.sup.5 = H, CH.sub.3 or C.sub.2 H.sub.5, useful as active ingredients of pharmaceutical preparation; processes for their preparation; chemical intermediates useful in said preparation; and methods for the treatment of infectious diseases.

Pharmaceutical preparations containing .alpha.-aminopenicillins

New esters of cephalosporins of the formula ##EQU1## wherein R.sup.1 is a substituted or unsubstituted alkyl, cycloalkyl, aryl or heterocyclic group, R.sup.2 is S--R.sup.4 wherein R.sup.4 is a methyl, ethyl, benzyl or heterocyclic group, a xanthate, dithiocarbamate, thiouronium, azido, alkoxy, hydrogen, substituted or unsubstituted alkanoyloxy, carbonyloxy or 1-pyridinium group, R.sup.3 is ##EQU2## wherein R.sup.5 is hydrogen, methyl or ethyl, X.sup.2 is O or NH, R.sup.6 is a basic group, R.sup.7 is a substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl or heterocyclic group, X.sup.1 is O or S, Y.sup.1 is hydrogen, a hydroxy, alkyloxycarbonyl, halogen, azido, a substituted or unsubstituted amino group, a carboxyl group, the group --COOR.sup.3, or a nitrite group, n is 0 or 1 and m is 0 or 1, useful as active ingredients of pharmaceutical preparations; processes for their preparation; and methods for the treatment of infectious diseases.

Cephalosporin and pharmaceutical preparations containing the same

Penicillin esters of the formula ##EQU1## wherein R.sup.1 is alkyl containing from one to eight carbon atoms, phenyl, thienyl, furyl, or phenyl substituted with one or more members of the group consisting of halogen, hydroxy, and amino, R.sup.2 is selected from the group consisting of --SO.sub.3 H, tetrazolyl, --NHSO.sub.2 R.sup.4, ##EQU2## and AND WHEREIN R.sup.3 is selected from the group consisting of ##EQU3## The radicals R.sup.4 -R.sup.10, X.sup.1 and X.sub.2 are defined in the specification. The esters are well resorbed at oral administration.

Growing community of inventors

Sodertalje, Sweden

Bertil Ake Ekstrom