Hoffmann-la Roche Inc.

Berthold Szperalski

Ulrich Behrendt

Wolfram Weber

Franz-Josef Gerner

Eckehard Walitza

Horst Eberhardt

Reinhard Gergen

Gerhard Herres

The invention relates to a method for reducing glucose consumption during cultivation of animal cells, which comprises cultivating animal cells in the presence of a bi- or tricarbonic acid or a salt thereof at a concentration of about 1 to 50 mmol/l.

Methods for growing mammalian cells in vitro

The present invention relates to hollow fiber membrane modules for use as 'immersion modules' in filtration and/or dialysis methods, in particular whenever impairments due to fouling effects are expected from the use of liquids that are contaminated or lead to deposits. The hollow fiber membrane module comprises at least one housing and a plurality of tubular hollow fiber membranes which are arranged parallel to one another in and/or around the housing in a packing space, wherein the volumetric ratio of all the hollow fiber membranes arranged in the packing space to the packing space is less than 20%. Methods for producing such hollow fiber membrane modules are also provided.

Hollow fiber membrane module

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Penzberg, Germany

Berthold Szperalski