Dr. Karl Thomae Gmbh

Boehringer Ingelheim Gmbh

Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Dr. Karl Tomae Gmbh

Berthold Narr

Erich Muller

Josef Nickl

Josef Roch

Walter Haarmann

Norbert Hauel

Johannes M Weisenberger

Jacques Van Meel

Wolfgang Wienen

Michael Entzeroth

Andreas Bomhard

Armin Heckel

Uwe Joerg Ries

Joachim Heider

Klaus Reinhold Noll

Manfred Psiorz

Walter Kobinger

Christian Lillie

Wolfgang Eisert

Thomas Muller

Willi Diederen

Manfred Reiffen

Rainer Zimmermann

Rudolf Kadatz

Jurgen Dammgen

Wolfgang Schroter

Wolfgang Grell

Andres Bomhard

Johannes-Maximilian Weisenberger

The invention relates to benzimidazoles of the formula ##STR1## in which R.sub.1 to R.sub.4 are as defined in claim 1,

Benzimidazoles, medicaments containing these compounds and processes for

The invention relates to benzimidazoles of general formula ##STR1## wherein R.sub.1 to R.sub.4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are useful, in particular, as angiotensin antagonists.

Benzimidazoles, pharmaceutical compositions containing these compounds

The invention relates to benzimidazoles of the formula ##STR1## in which R.sub.1 to R.sub.2 are as defined in claim 1, 1 and 3 isomer mixtures thereof and addition salts thereof which have valuable properties. In particular, the novel compounds are angiotensin II antagonists.

Benzimidazoles and medicaments containing these compounds

A phenylalkyl derivative of the formula ##STR1## wherein R.sub.a to R.sub.f, A and B are substituents and n is the number 0 or 1. These phenylalkyl derivatives possess angiotensin antagonist activity.

Phenylalkyl derivatives, with pharmaceutical activity

The invention relates to substituted benzimidazolyl derivatives of the general formula ##STR1## wherein A and R.sub.a to R.sub.c are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof which have valuable properties. These compounds have valuable pharmacological properties, particularly angiotensin-antagonistic effects and preferably angiotensin-II-antagonistic effects.

Substituted benzimidazolyl derivatives and pharmaceutical compositions

Imidazo[1,2-a]pyridines of the formula ##STR1## wherein R.sub.a to R.sub.e are as defined herein, the enantiomers and the salts thereof, which are useful as angiotensin antagonists and for treating conditions treatable with angiotensin antagonists.

Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these

Disclosed are new cyclic amine derivatives of the formula I ##STR1## wherein the substituents are defined in the specification. These compounds are useful as for treating sinus tachycardia.

Cyclic amine derivatives, pharmaceutical compositions containing these

The present invention relates to new heteroaromatic amine derivatives of general formula ##STR1## wherein the substituents are defined hereinbelow, which have valuable pharmacological properties, particularly a heart rate lowering activity and a positive inotropic activity.

Heteroaromatic amine derivatives

The invention relates to new sulphonamidoethyl compounds having valuable pharmacological properties, particularly anti-thrombotic properties, and which are also thromboxane antagonists.

Sulphonamidoethyl compounds and pharmaceutical compositions comprising

The invention relates to new benzenesulphonamidoindanyl compounds useful in the treatment and prophylaxis of thromboembolic diseases, arteriosclerosis and tumor metastasis.

Benzenesulphonamidoindanyl compounds

Heteroaromatic amine derivatives, pharmaceutical compositions containing

The present invention relates to new naphthyl derivatives of general formula ##STR1## wherein N represents the number 1 or 2,

Naphthyl derivatives, pharmaceutical compositions containing these

The invention relates to new sulphonamido-ethyl compounds having the following structure: ##STR1## wherein R.sub.1 is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R.sub.2 is hydroxycarbonyl or alkoxycarbonyl bonded via alkylene or alkenylene, or a 4,5-dihydro-pyridazin-3-one-6-yl or pyridazin-3-on-6-yl group optionally substituted on a ring carbon by C.sub.1 -C.sub.3 alkyl and X is substituted or unsubstituted imino, oxygen or sulphur, which compounds may be used to prevent arteriosclerosis or tumor metastasis, and are antitrombotic and thromboxane antagonists.

Growing community of inventors

Biberach, Germany

Berthold Narr