Boehringer Ingelheim Microparts Gmbh

Berthold Lange

Dirk Klaus Osterloh

Ying Yu

Christian Schoen

Dirk Kurowski

Tobias Rodenfels

Thomas Willms

Wolfgang Stoeters

Thorsten Joedicke

Markus Voigt

Tobias Eichmann

Dirk Osterloh

A device and a method are proposed for actuating a carpule, in which a piston is displaced in the carpule by means of a ram that is telescopically extensible by rotation, and in this way a liquid medicament formulation is expelled. For carrying out different processes, different operating movements are provided, particularly the operation of an operating element in different directions and/or the operation of different operating elements. This promotes simple, intuitive and safe operation.

Device and method for actuating a carpule

Methods and apparatus for mixing at least one sample solution with at least one reagent in at least one chamber of a microfluidic cartridge such that at least one reagent (R) is supplied to the sample solution (P) and brought into contact therewith by way of at least one movable component. In this way the loss of sample liquid or analyte can be reduced.

Method for mixing at least one sample solution having at least one reagent, and device

Methods and apparatus provide for filling at least one cavity with a liquid via: partly filling a cavity of a semifinished product containing at least two cavities, covering the semifinished product at least in some areas, so as to prevent the escape of liquid from the semifinished product, displacing at least some of the liquid from the already partially filled cavity, such that at least one other cavity is completely filled by a portion of the displaced liquid and another portion of the displaced liquid at least partially fills at least one overflow.

Method for filling a cavity, in particular a blister of a blister packaging, with a liquid, and semifinished product for use in such a method

The invention relates to a container () for a fluid for metering a reagent into a microfluidic system. The container comprises a chamber () and a first film () which seals off the chamber () so that the fluid is encapsulated in the chamber. Advantageously, the first film () is an aluminum sealing film. A second film () is sealingly arranged on the first film, for example by adhesive bonding of the film layers. The films differ in their tear strength such that when pressure is applied simultaneously to both films the first film tears while the second film deforms elastically and/or plastically. By tearing the first film a connection is produced between the container chamber and an inlet channel so that a fluid contained in the chamber flows into the microfluidic system.

Fluid metering container

A device, particularly a microfluidic system, is proposed, in which two cavities are arranged spatially close to one another and are sealed off from one another by a common cover. A fluidic connection can be produced between the cavities by movement of a pin-shaped body towards the cover. In this way it is possible to release a reagent in controlled manner without having to put it under pressure.

Growing community of inventors

Werne, Germany

Berthold Lange