Bayer Aktiengesellschaft

Hoffmann-la Roche Inc.

Bayer Akt.

Bernward Garthoff

Horst Meyer

Andreas Knorr

Stanislav Kazda

Axel Ingendoh

Arno Widdig

Hans-Joachim Kabbe

Ulrich Niewohner

Gunter Thomas

Siegfried Goldmann

Egbert Wehinger

Bodo Junge

Harald Horstmann

Eike Moller

Ekkehard Niemers

Marcel Gerold

Fridolin Hefti

Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together with the phenyl ring, the group ##STR2## R.sup.1 is alkyl of 1 to 4 C atoms, which is optionally substituted by alkoxy of 1 to 4 C atoms,

Antihypertensive combination products containing a dihydropyridine and a

An alkenecarboxylic acid of the formula ##STR1## in which R.sup.1 denotes hydrogen, aryl, substituted aryl or a straight-chain or cyclic, saturated or unsaturated aliphatic hydrocarbon radical, which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl, and which is optionally substituted by hydroxyl, alkoxy, alkyl, trifluoromethyl, halogen, phenyl, alkoxycarbonyl or dialkylamino, the two alkyl radicals together with the nitrogen atom optionally forming a 5 to 7-membered ring, which optionally contains a heteroatom from the group comprising O, S, NH or N-alkyl and these aforementioned alkyl and phenyl radicals in turn optionally being substituted by halogen, trifluoromethyl, alkyl, aryl, aralkyl, alkoxy, alkylmercapto or SO.sub.2 -alkyl,

Imidazothiadiazolealkylene carboxylic acids

A carbonyl compound of the formula ##STR1## in which R.sup.1 denotes hydrogen, aryl, substituted aryl or a straight-chain or cyclic, saturated or unsaturated aliphatic hydrocarbon radical, which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl, and which is optionally substituted by hydroxyl, alkoxy, alkyl, trifluoromethyl, halogen, phenyl, alkoxycarbonyl or dialkylamino, the two alkyl radicals together with the nitrogen atom optionally forming a 5 to 7-membered ring, which optionally contains a heteroatom from the group comprising O, S, NH or N-alkyl and these aforementioned alkyl and phenyl radicals in turn optionally being substituted by halogen, trifluoromethyl, alkyl, aryl, aralkyl, alkoxy, alkylmercapto or SO.sub.2 -alkyl,

Amidazothiodiazone carbonyl compounds useful to prepare novel

The invention concerns a combination of dihydropyridine derivatives with compounds which inhibit the formation of enzymes which control the conversion of angiotensin I into angiotensin II and their use as antihypertensive agents.

Combination of dihydropyridines with angiotensin converting

Substituted benzopyrans of the formula ##STR1## in which --A-- is a single or double bond,

Substituted aminomethyl benzopyrans having anti-hypertensive activities

Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R.sup.1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl and which is optionally substituted,

Novel hypotensive imidazothiadiazolealkanecarboxamides

Novel substituted 4-hydroxy-benzopyrans of the formula ##STR1## in which X is a single bond, ##STR2## and the other radicals can have various meanings, or pharmaceutically acceptable addition salts thereof, which are active on the circulation system.

Circulation active novel substituted 4-hydroxy-benzopyrans

Pyridopyrimidines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic, exhibit circulation active properties, especially renal vasodilating and diuretic action.

Pyridopyrimidines, pharmaceutical compositions and use

The invention relates to aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, processes for their preparation, intermediates which are used in their preparation, medicaments containing said active compounds for use as antihypertensive agents, diuretics and uricosuric agents. Also included in the invention are methods for use of said compounds and compositions for the above indicated indications. The active compounds are identified herein by formula (I) and the novel intermediates used in preparing the compounds of Formula (I) are those described herein under Formula (II).

Aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides,

The invention relates to pharmaceutical compositions containing active ingredients of Formula (I) and methods for the use of said compositions to treat cardiac insufficiencies. Also included in the invention are methods of the manufacture of said active ingredients of Formula (I). The invention includes, additionally, compounds of Formula (I).

Agents for combating circulatory illnesses and their use

Novel hypotensive imidazothiadiazolealkenecarboxamides

A method of combating a disorder of the salt balance in a patient afflicted therewith comprising administering to such patient a salt-balance restoring effective amount of a vasodilating 1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical. The salt balance disorder may accompany the hypertensive disease or may also be aggravated by administering to such a patient a hypertension reducing agent.

1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic acid

Compounds of the formula ##STR1## in which R.sup.1 is an optionally substituted aryl or heteroaryl radical,

Hypotensive 2-nitro-1,1-ethenediamines

The invention relates to imidazoazole-alkenoic acid amides of Formula (I) and methods for their production. Also included in the invention are compositions containing said alkenoic acid amides and methods for the use of said alkenoic acid amides and the compositions containing them. In addition, the invention includes the intermediate carbonyl compounds of Formula (II) and the intermediate alkenoic acids of Formula (V) as well as methods for their preparation.

Growing community of inventors

Hilden, Germany

Bernward Garthoff