Massachusetts Institute of Technology

Novartis Ag

Politecnico Di Torino

Novartis Pharma Ag

Bernhardt Levy Trout

Bernhard Helk

Vladimir Voynov

Naresh Chennamsetty

Veysel Kayser

Alexander H Slocum, Jr

Neeraj Jagdish Agrawal

Allan Stuart Myerson

Nikhil Padhye

Trevor Alan Hatton

Gregory C Rutledge

David Moore Parks

Won Sik Kim

Patrick Seamus Doyle

Yi Du

Jung-Hoon Chun

Salvatore Mascia

Keith M Forward

Curtiss Paul Schneider

Emily Chang

Himanshu Hemant Dhamankar

Keith Chadwick

Roberto Pisano

James M B Evans

Ryan Richard Slaughter

Nicholas M Sondej

Mao Wang

Luigi Carlo Capozzi

Indrani Bhattacharyya

Blair Kathryn Brettmann

Ying Diao

Matthew E Helgeson

James Mb Evans

System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.

Lyophilization systems and methods

The disclosure in some aspects relates to systems and related methods for the continuous freeze-drying of materials (e.g., pharmaceuticals) with high speed and control.

Freeze-drying methods and related products

Provided herein are high-throughput methods for identifying a candidate antibody based on viscosity of the candiate antibody.

Computer-implemented methods of determining protein viscosity

Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures.

Plasticity induced bonding

The present disclosure relates to methods and computational tools based, at least in part, on computer simulations that identify hot-spot amino acid residues and binding-region amino acid residues of a protein.

Methods to identify amino acid residues involved in macromolecular binding and uses therefor

Methods and apparatuses for bonding polymeric parts are disclosed. Specifically, in one embodiment, the polymeric parts are bonded by plastically deforming them against each other while they are below the glass transition temperatures. A method includes: placing a first polymeric part in contact with a second polymeric part; and plastically deforming the first polymeric part and the second polymeric part against each other to bond the first polymeric part to the second polymeric part. Additionally, during the plastic deformation, a temperature of the first polymeric part is less than a glass transition temperature of the first polymeric part and a temperature of the second polymeric part is less than a glass transition temperature of the second polymeric part.

Methods and systems for manufacturing a tablet are generally provided. Certain embodiments comprise electrodepositing (e.g., electrospinning) a material (e.g., the tablet material, for example, within a fluid) onto a substrate. The substrate can be, for example, an elongated rod. In some such embodiments, after material has been electrodeposited onto the substrate, a die comprising a cavity and the substrate can be moved relative to each other such that the electrodeposited material is at least partially stripped from the substrate and/or at least partially deposited into the cavity of the die. Some embodiments comprise compressing the material in the cavity to form a tablet.

Methods and systems for manufacturing a tablet

The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.

Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor

The present invention generally relates to methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species. In some embodiments, the methods and systems allow for the controlled crystallization of a molecular species in a selected polymorphic form. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).

Methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species

The invention provides HER2-binding proteins and VEGF-A-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.

HER2- and VEGF-A-binding proteins with enhanced stability

The present disclosure relates to immunoglobulins with reduced aggregation and compositions, methods of generating such immunoglobulins with computational tools and methods of using such immunoglobulins particularly in the treatment and prevention of disease.

Immunoglobulins with reduced aggregation

The present disclosure relates to immunoglobulins and immunoglobulin conjugates with reduced oligomerization and efficient labeling and compositions, methods of generating such immunoglobulins and immunoglobulin conjugates and methods of using such immunoglobulin conjugates particularly in the treatment and prevention of disease.

Methods for identification of sites for IgG conjugation

Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet.

Layer processing for pharmaceuticals

The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).

Growing community of inventors

Lexington, MA, United States of America

Bernhardt Levy Trout