Natera, Inc.

Bernhard Zimmerman

Matthew Rabinowitz

Zachary Demko

George Gemelos

Matthew Micah Hill

Milena Banjevic

Allison Ryan

Styrmir Sigurjonsson

Huseyin Eser Kirkizlar

Onur Sakarya

Johan Baner

Tudor Pompiliu Constantin

Joshua Babiarz

Lane A Eubank

Methods for non-invasive prenatal paternity testing are disclosed herein. The method uses genetic measurements made on plasma taken from a pregnant mother, along with genetic measurements of the alleged father, and genetic measurements of the mother, to determine whether or not the alleged father is the biological father of the fetus. This is accomplished by way of an informatics based method that can compare the genetic fingerprint of the fetal DNA found in maternal plasma to the genetic fingerprint of the alleged father.

Methods for non-invasive prenatal paternity testing

The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of DNA from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. In an embodiment, the mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias.

Methods for non-invasive prenatal ploidy calling

Growing community of inventors

Manteca, CA, United States of America

Bernhard Zimmerman