Bayer Intellectual Property Gmbh

Bernhard Weingaertner

Jörn Kalinowski

Alfred Pühler

Patrick Schwientek

Hermann Wehlmann

Winfried Rosen

Klaus Selber

Udo Wehmeier

The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type&#x2014;and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene- and DNA-sequences, as well as protein-sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield.

Genomics of actinoplanes utahensis

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Wülfrath, Germany

Bernhard Weingaertner