Behring Diagnostics Gmbh

Hoechst Aktiengesellschaft

Schering Corporation

New York University

Behringwerke Aktiengesellschaft

Other

Sanofi-a Ventis Deutschland Gmbh

Biotest Ag

Asta Pharma Aktiengesellschaft

Behring Diagnositcs Gmbh

Bernhard W Fleckenstein

Frank Neipel

Gerhard Jahn

Helmut Fickenscher

Andrea Knappe

Rene De Waal Malefyt

Michael Broker

Walter Schaffner

Michael Mach

Alvin E Friedman-Kien

Michael Boshart

Brigitte Biesinger-Zwosta

Jens-Christian Albrecht

Bernd Traupe

Birgit-Christine Scholl

Frank Weber

Thomas Harrer

Ralph Grassmann

Andreas Baur

Karoline Dorsch-Hasler

Yao-Qi Huang

Karoline Dorsch-H&auml;sler

Dieter Lang

Armin Ensser

Joachim Kalden

Jens Christian Albrecht

Ingrid Mueller-Fleckenstein

Yao Qi Huang

Sigrid Nick

Helmut Flickensher

The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and treatment of human diseases such as kaposi sarcoma, Castleman's disease, multiple myeloma, kidney cell carcinoma, mesangial proliferative glomerulonephritis or B cell lymphoma.

Viral interleukin-6

Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

Mammalian cytokine; related reagents

The invention relates to novel semaphorins which are distinguished by a particular domain structure and derivatives thereof, nucleic acids (DNA, RNA, cDNA) which code for these semaphorins, and derivatives thereof, and the use thereof. The present invention relates to semaphorins which have a novel, as yet undisclosed and unexpected domain structure and which possess a biochemical function in the immune system (immunomodulating semaphorins). The novel semaphorins are referred to as type L semaphorins (SemaL). They comprise an N-terminal signal peptide, a characteristic Sema domain and, in the C-terminal region of the protein, an immunoglobulin-like domain and a hydrophobic domain which represents a potential transmembrane domain.

Human semaphorin L (H-SemaL) and corresponding semaphorins in other species

AK155 polypeptides

Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using these reagents and diagnostic kits are also provided.

AK155 antibodies and binding fragments thereof

An enhancer has been located in the upstream region of the major immediate early gene of human cytomegalovirus and has been isolated, which enhancer is more active than that from SV40 and has a wide host cell spectrum. Hence, it is suitable for eukaryotic expression systems wherein it can be incorporated upstream or downstream of the structural gene or of the regulation region.

Enhancer for eukaryotic expression systems

Polypeptides encoded by Kaposi sarcoma-associated herpes virus the use thereof in diagnosis and therapy

The invention relates to the human herpesvirus type 6 protein p100 and parts thereof having its specific immunological properties. It further relates to antibodies directed to them and to the corresponding DNA sequences. They can be used in pharmaceutical or diagnostic compositions, optionally together with other HHV-6 proteins or the corresponding DNA sequences.

Human herpesvirus type 6 protein p100, the corresponding DNA sequences, their preparation and use

Selectable Herpesvirus saimiri vectors which have a selection gene inserted into a junction region of the L- and H-DNA are described. Vectors of this type are able persistently to infect human T cells and thus are suitable for the expression of foreign genes in human T cells. An additional advantage is that no infectious virus particles are produced during this.

Selectable vectors for human T cells

Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.

DNA encoding IL-10-like homologue; related reagents

The phosphorylated structural protein of molecular weight about 150 kd (pp 150) of human cytomegalovirus (HCMV) is highly immunogenic and is reliably recognised by human antisera. This protein can, after assignment and sequencing of the gene, be prepared, in whole or in immunogenic sections, by gene manipulation. Proteins of this type are suitable as reagents, for example in an ELISA, and as constituents of vaccines.

Structural phosphoprotein (PP150) of human cytomegalovirus, and the

Human herpesvirus type 6 protein p100, the corresponding DNA sequences,

Human herpesvirus type 6 protein p100, the corresponding DNA seqences,

Growing community of inventors

Wiesenthau, Germany

Bernhard W Fleckenstein