Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gmbh

Sharp Corporation

Toshiba Corporation

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Merck Kgaa

Bescrankter Haftung

Bernhard Scheuble

Georg Weber

Joachim Krause

Rudolf Eidenschink

Reinhard Hittich

Ludwig Pohl

Eike Poetsch

Andreas Wachtler

Herbert Plach

Hans A Kurmeier

Volker Reiffenrath

Takamasa Oyama

Ekkehard Bartmann

Thomas Geelhaar

Bernhard Rieger

Michael Romer

Hans-Adolf Kurmeier

Reinhard Hopf

Klaus Bofinger

Ulrich Finkenzeller

Waltraud Fehrenbach

Wolfgang Strittmatter

Uwe Hofmann

Hiroki Yoshitake

Gunther Haas

Klaus P Stahl

Zisi Fotev

Dieter Dorsch

Gunter Baur

Klaus Praefcke

Bernd Kohne

Axel Pausch

Peter Fuss

Detlef Güssow

Wadi Poules

Jürgen Hemberger

Detlef Pauluth

Fumiaki Funada

Ian Charles Sage

Shuichi Kohzaki

Shoichi Matsumoto

Michael Kompter

Masako Okada

Jurgen Eichler

Hitoshi Tomii

Kiyohiko Kawamoto

J&uuml;rgen Hemberger

Detlef G&uuml;ssow

Wachtler

Barbara Staudacher

Rudolf Fidenschink

G&uuml;nter Baur

Guter Baur

The invention relates to a matrix liquid crystal display containing integrated non-linear elements and a liquid crystal mixture which has a particularly high resistivity.

Matrix liquid crystal display

Described are matrix liquid crystal displays having two plane parallel support plates which together with a frame form a cell, integrated non-linear elements for switching individual picture elements on the support plates and a nematic liquid crystal mixture which is present in the cell and has a positive dielectric anisotropy and high resistivity. The liquid crystal mixture has a nematic phase range of at least 60&#xb0; C., a maximum viscosity at 20&#xb0; C. of 30 mPa&#xb7;s and a mean dielectricity constant &#x3b5;&#x2266;8. The liquid crystal mixture contains: a) at least 10% by weight of a liquid-crystalline component B having one or more compounds of the following formulae: and b) up to 90% by weight of a liquid-crystalline component A having one or more compounds with a dielectric anisotropy of &#x2212;1.5 to 1.5 of the formula I: 

A naturally occurring protein isolated from the saliva of the medicinal leechis described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from acDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.

Protein for blocking platelet adhesion

A naturally occurring protein isolated from the saliva of the medicinal leechis described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from acDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.

A naturally occurring protein isolated from the saliva of the medicinal leech is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.

Electrooptical system

Supertwist liquid crystal displays having very short switching times are obtained if the nematic liquid crystal mixture contains at least one component chosen from group A consisting of compounds of the formulae AI to AVI:

Supertwist liquid crystal display

Supertwist liquid crystal displays having very short switching times are obtained if the nematic liquid crystal mixture contains at least one component chosen from group A consisting of compounds of the formulae AI to AVI: ##STR1## wherein R.sup.1 and R.sup.2 in each case independently of one another are each R and R is alkyl having 1-12 C atoms, wherein one or two non-adjacent CH.sub.2 groups can also be replaced by --O--, --CH.dbd.CH--, --CO--, --O--CO-- or --CO--O--, and up to four other components.

Fluorobenzene derivatives of formula I, ##STR1## in which R an alkenyl radical as further defined in the specification,

Fluorobenzene derivatives and liquid-crystalline medium

The invention relates to liquid crystal compounds having a terminal structure in accordance with formula 1, 2, 3 or 4:

Fluorinated liquid crystal compounds and liquid crystal medium

Supertwist liquid crystal displays having outstanding properties are obtained if the nematic liquid crystal mixture is based on components selected from group A comprising compounds of the formulae IIa to IIk: ##STR1##

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Yokohama, Japan

Bernhard Scheuble