Bayer Aktiengesellschaft

Troponwerke Gmbh & Co Kg

Troponwerke Gmbh & Co.

Bernhard Pelster

Hans-Josef Buysch

Alexander Klausener

Romanis Fruchtmann

Gerd Fengler

Wolfgang Opitz

Hans-Dieter Dell

Detlef Schierstedt

Reinhold Kraus

Elisabeth Perzborn

Klaus Sasse

Bodo Junge

Harald Horstmann

Siegfried Raddatz

Friedel Seuter

Peter Stadler

Hermann Oediger

Christian Kohlsdorfer

Oswald Lockhoff

Trevor S Abram

Haireddin Jacobi

Graham Sturton

Mithat Mardin

Hans-Georg Opitz

Udo Krupka

Walter Gauss

Hartmut Kiehne

Michael Hammond

Hans Plumpe

New potent lipoxygenase inhibitors which are 1H-pyrido-[2,3-b][1,4] thiazines are disclosed. The new thiazines are of the formula ##STR1## in which R.sup.1 denotes hydrogen, halogen, optionally substituted alkyl or alkoxy or the group ##STR2## in which R.sup.5 and R.sup.6 are identical or different and denote hydrogen, optionally substituted alkyl or aryl, or can be linked to form a 5- or 6-membered heterocyclic ring,

1H-pyrido-(2,3-b) (1,4)-thiazines

1-H-pyrido-[3,2-b][1,4]-thiazines of the formula ##STR1## are prepared by the reaction of 2-halogenocarbonyl compounds an 2-amino-3-pyridinethiols. These compounds are useful as medicaments especially as inhibitors of lipoxygenase.

1-H-pyrido-[3,2-b][1,4]-thiazine

A diaryl sulphide derivative of the formula ##STR1## in which R.sup.1 represents a thiazolamino radical of the formulae ##STR2## wherein R.sup.5 represents hydrogen, alkyl, aralkyl or acyl,

Diaryl sulphide derivatives

A method of combating rheumatic diseases which comprises administering to a patient afflicted therewith an amount effective to combat such disease of a compound of the formula ##STR1## in which Z is a glycosyl radical bonded via the anomeric carbon atom,

N-glycosylated carboxylic acid derivatives as agents for combating

The invention relates to 1-heteroaryl-4-aryl-pyrazolin-5-ones, a preparation process and the use in combating diseases, in particular for use as lipoxygenase inhibitors.

1-Heteroaryl-4-aryl-pyrazolin-5-ones for use as medicaments

New compounds of the formula ##STR1## in which R.sub.1 is an allylamino, acetylamino or propionylamino radical,

1,4-naphthoquinone derivatives having anti-inflammatory action

The invention relates to depot formulations containing, as an active antiinflammatory and/or analgesic agent a compound of Formula I, infra together with a suspension medium. Typical suspension agents are glycerides and/or esters of mono- or poly-hydric alcohols as well as selected ethers, alcohols and amides.

Depot antiinflammatory agents

The invention relates to quinazolinone derivatives and of formula (I) as defined herein and processes for the production of said derivatives. Also included in the invention are pharmaceutical compositions containing a compound of said formula (I) as active ingredient and the use of said compounds and compositions as anti-inflammatory agents.

Quinazolinone derivatives

Growing community of inventors

St. Augustin, Germany

Bernhard Pelster