Wayne State University

UniversitÄt Bayreuth

Charité – Universitätsmedizin Berlin

Martin-Luther-Universität Halle-Wittenberg

Bernhard Max Biersack

Fazlul H Sarkar

Rainer Schobert

Subhash Padhye

Hossein Salimnia

Michael Höpfner

Katharina Mahal

Thomas Müller

Disclosed herein are antibacterial compounds, pharmaceutical compositions including the antibacterial compounds, and methods of treating bacterial infections using the compounds and compositions.

Antibacterial compounds and methods of use thereof

The present invention relates to a 4,5-diarylimidazole derivative of formulae (I), (II) or (III): or a pharmaceutically acceptable salt thereof, wherein the 4,5-diarylimidazole derivative has a hydroxamic acid residue at a first aryl ring and a residue R1 at a second aryl ring; and wherein R1 is hydrogen, a halogen atom or an unsubstituted or substituted alkoxy group; R2 is independently selected from an unsubstituted or substituted alkyl, alkoxy or alkene group; M is a metal atom; L is a halogen atom, an unsubstituted or substituted phosphane, sulfane, arene or alkene group or a 4,5-diarylimidazole-derivative of formula (I); and n is an integer of from 1 to 5. 

4,5-diarylimidazole derivatives as HDAC inhibitors

The present invention relates to specific analogs of combretastatin, in particular the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising the compounds, as well as their medical use, in particular in the treatment or prevention of cancer, including multidrug-resistant cancer. 

Combretastatin analogs for use in the treatment of cancer

Growing community of inventors

Prebitz, Germany

Bernhard Max Biersack