Sanofi Pasteur Sa

Glatt Gmbh

Glatt Air Techniques, Inc.

Glatt Process Technology Gmbh

Bayer Pharma Aktiengesellschaft

Csl Behring Gmbh

Bernhard Luy

Manfred Struschka

Matthias Plitzko

Thomas Gebhard

Matthias Tondar

David M Jones

Richard Andrew Smith

John Patrick Kennedy

Frank Maurer

Matthias Georg Tondar

Markus J Baettig

Roland Kaiser

Armin Prasch

Christian Zerillo

Hans Leuenberger

Carsten Olbrich

Mirna Rapp

Jochen A Dressler

Stefan Christian Schneid

Armin Karl Theodor Prasch

Mathias Tondar

Ulf Konig

Armin K T Prasch

A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer comprising a rotary drum for receiving the frozen particles, and a stationary vacuum chamber housing the rotary drum, wherein for the production of the particles under closed conditions the vacuum chamber is adapted for closed operation during processing of the particles; the drum is in open communication with the vacuum chamber; and at least one transfer section is provided for a product transfer between a separate device of the process line and the freeze-dryer, the freeze-dryer and the transfer section being separately adapted for closed operation, wherein the transfer section comprises a temperature-controllable inner wall surface.

Process line for the production of freeze-dried particles

A heating device () for heating particles to be freeze-dried in a rotary drum () of a freeze-dryer () is provided, the device comprising at least one radiation emitter () for applying radiation heat to the particles, and a tube-shaped separator () for separating the particles from the at least one emitter (), The separator () being integrally closed at one end and separating an emitter volume () encompassing the at least one emitter () from a drum process volume () inside the drum (), wherein the heating device () protrudes into the drum process volume () such that said integrally closed end of the separator () is arranged inside the drum () as a free end.

Heating device for rotary drum freeze-dryer

The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.

Liquid feeding device for the generation of droplets

A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer () for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer () comprising a rotary drum () for receiving the frozen particles, and a stationary vacuum chamber () housing the rotary drum (), wherein for the production of the particles under closed conditions the vacuum chamber () is adapted for closed operation during processing of the particles. The drum () is in open communication with the vacuum chamber () and at least one transfer section () is provided for a product transfer between a separate device of the process line and the freeze-dryer (), the freeze-dryer () and the transfer section () being separately adapted for closed operation, wherein the transfer section () comprises a temperature-controllable inner wall surface.

A heating device () for heating particles to be freeze-dried in a rotary drum () of a freeze-dryer () is provided, the device comprising at least one radiation emitter () for applying radiation heat to the particles, and a tube-shaped separator () for separating the particles from the at least one emitter (). The separator () being integrally closed at one end and separating an emitter volume () encompassing the at least one emitter () from a drum process volume () inside the drum (), wherein the heating device () protrudes into the drum process volume () such that said integrally closed end of the separator () is arranged inside the drum () as a free end.

A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of: a) freezing droplets of a solution comprising factor VIII to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.

Method for the production of freeze-dried pellets comprising factor VIII

A process line () for the production of freeze-dried particles under closed conditions is provided, the process line comprising at least the following separate devices: a spray chamber () for droplet generation and freeze congealing of the liquid droplets to form particles, and a bulk freeze-dryer () for freeze drying the particles, wherein a transfer section () is provided for a product transfer from the spray chamber () to the freeze-dryer (), for the production of the particles under end-to-end closed conditions each of the devices () and of the transfer section () is separately adapted for closed operation, and the spray chamber () is adapted for separation of the liquid droplets from any cooling circuit.

A process line () for the production of freeze-dried particles under closed conditions comprising at least a spray chamber () for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer () for freeze drying the particles, the freeze-dryer () comprising a rotary drum for receiving the particles. Further, a transfer section () is provided for a product transfer from the spray chamber () to the freeze-dryer (). For the production of the particles under end-to-end closed conditions each of the devices () and of the transfer section () is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.

A rotary drum () for use within a vacuum chamber () in a vacuum freeze-dryer () for the bulkware production of freeze-dried particles is provided. The drum () is in open communication with the vacuum chamber () and comprises a main section () terminated by a front plate () and a rear plate (), the rear plate () is adapted for connection with a rotary supporting shaft () for rotary support of the drum (), and the rear plate () is permeable for sublimation vapor from freeze-drying the particles.

Rotary drum for use in a vacuum freeze-dryer

The invention concerns a spray nozzle for a fluidized bed device, said nozzle comprising a central liquid outlet () for a liquid coating agent and an annular air outlet () for conveying spraying air coaxially. An enclosing body () having a central recess () is maintained in a wall of the box of the fluidized bed device. Said enclosing body () is connected to a spraying air source through an air duct () and an axially mobile nozzle head () is centrally mounted inside said enclosing body (). Said nozzle head () is connected to a liquid coating agent source through a liquid duct (), said liquid duct () having a flexible tubular section () and being centrally guided inside the air duct ().

Spray nozzle for fluidized bed device

A process for measuring, monitoring and/or controlling directed product movements of fluidized products in process systems () selected from fluidized bed and spouted bed systems during a spraying process for coating and/or granulation, which includes, with the aid of one or more microwave sensor devices (), injecting microwave radiation without contact into one or more product streams, receiving the microwave radiation reflected by the particles of the particular product stream and, on the basis of the microwave radiation received, forming and transmitting a measurement signal for the characterization of the product stream, the corresponding use of microwave sensor devices () and correspondingly equipped apparatus ().

Measurement, monitoring and control of directed product movements in a Wurster-arrangement and suitable systems

The invention relates to a flowable fibrin adhesive granulate containing thrombin, Factor XIII, fibrinogen, and a calcium salt in the form of granules with a particle size of more than 50 &#x3bc;m to 1000 &#x3bc;m. Said granulate is useful for the healing of wounds in surgery, tissue therapy and/or as supporting material for biological factors. The invention also relates to an effervescent granulate and an effervescent powder for producing a foam that is suitable for hemostasis. The invention further relates to preparations to arrest bleeding containing a non-woven fabric for wounds consisting of a biodegradable supporting material that is coated with a fibrin glue granulate mixture or mixed granulate.

Fibrin adhesive granulate and method for its preparation

A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. The product container further includes an upper end connected to an expansion chamber and a lower end including an orifice plate having a plurality of openings for passage of fluidized air or gas. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. Particles located within the product container circulate upwardly through the partition and the coating liquid spray, between the up bed and the down bed. A central discharge assembly is provided at the lower end of the product containers for emptying particles from the machine. Air is preferably discharged from the manifold during the emptying process to help direct particles towards the discharge assembly.

Product discharge and cleaning assembly for an apparatus for coating tablets

A fluidized bed apparatus for applying a coating liquid onto the surface of particles includes a vertically disposed cylindrical product container having a peripheral wall, at least one cylindrical partition defining a centrally located up bed region and a peripherally located down bed region. A nozzle is centrally located through the orifice plate and is adapted to generate a spray of coating liquid upwardly into the up bed. A nozzle ramp is provided around the nozzle. The nozzle ramp is generally cusp shaped and includes nozzle-ramp surface. The nozzle ramp is centrally positioned around the nozzle and is directed upwardly towards the partition so that the nozzle-ramp surface directs particles moving generally horizontally across the orifice plate from the down bed upwardly into the partition and the up bed. The nozzle ramp may further include air passages for passing fluidized air upwardly to the nozzle-ramp surface.

Growing community of inventors

Freiburg, Germany

Bernhard Luy