Chimerix, Inc.

Bernhard Lampert

Merrick R Almond

Roy Wendell Ware

Ernest Randall Lanier, Jr

Ernest Randall Lanier

The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: 

Nucleoside phosphonate salts

The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

Phosphonate ester derivatives and methods of synthesis thereof

The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein Mis Na, Li, K, Ca, Mg, or NRRRRand R, R, Rand Rare each independently hydrogen or Calkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof. 

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Rougemont, NC, United States of America

Bernhard Lampert