Boehringer Mannheim Gmbh

Cancerforskningsfonden Af 1989

Bernhard Konig

Alfred Mertens

Christoph Kessler

Harald Zilch

Rudolf Seibl

Josef Eberle

Frank Seela

Herbert Leinert

Hans Seidel

Ulrich Kohnert

Ulrich Weidle

Rainer Gumbiowski

Vincent Ellis

Ilse Bartke

Michael Ploug

Helmut Rosemeyer

Ulrike Leser

Keld Dano Slashed

Edith Koch

Angelika Roling

Werner Bourgeouis

Ulrich Pessara

The invention relates to an antibody which inhibits the binding between u-PA and u-PAR to an extent of at least 90% in an assay as defined in the specification, or an active fragment or immunological equivalent of said antibody. Examples of such antibodies are deposited Jul. 7, 1994 at Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSM) with accession numbers DSM ACC2178 and DSM ACC2179 under the terms and conditions of the Budapest Treaty. The invention furthermore relates to a method for detecting or quantifying u-PAR or a glycosylation variant of u-PAR in a sample by use of an antibody according to the invention. Furthermore, the invention relates to a method for the manufacture of a therapeutic agent for preventing or counteracting localized proteolytic activity using of an antibody of the invention as well as to use of an antibody according to the invention for the preparation of a diagnostic agent which is capable of targeting a diagnostic to a cell that contains a u-PAR on the surface.

Hydrophobic u-PAR binding site

Method of determining polymerase activity by incubating the polymerase with a template nucleic acid, one detectable mononucleoside triphosphate and one immobilizable nucleoside triphosphate, binding the immobilizable nucleotides to a solid phase and detecting the bound delectable nucleotides and tests based thereon.

Reagents and kits for determining polymerase activity

Purine analog nucleoside and nucleotide compounds

Method of determining polymerase activity

Use of thiazoloisoindolinone derivatives as antiviral medicaments

Growing community of inventors

Berg, Germany

Bernhard Konig