Byk Gulden Lomberg Chemische Fabrik Gmbh

Nycomed Gmbh

Altana Pharma Ag

Takeda Gmbh

Bernhard Kohl

Gerhard Grundler

Walter Palosch

Bernd Mueller

Bernd Müller

Jörg Senn-Bilfinger

Wilm Buhr

Georg Rainer

Rolf-Peter Hummel

Peter Jan Zimmermann

Guido Hanauer

Ralf Steffen Weingart

Ernst Sturm

Wolfgang-Alexander Simon

Volker Figala

J Org Senn-Bilfinger

Reinhard Huber

Michael David

Felix Huth

Oliver Von Richter

Karl Zech

Dieter Haag

Bernd MÜLLER

A composition comprising: roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.

Process for the preparation of roflumilast

A method for the treatment of chronic obstructive pulmonary disease (COPD), including administering to a patient suffering from COPD, a therapeutically effective amount of roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.

The invention relates to novel processes for the preparation of high-purity roflumilast.

The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.

Isotopically substituted proton pump inhibitors

The invention relates to a novel process for preparing an optically pure PPI having a sulfinyl structure using a chiral zirconium complex or a chiral hafnium complex.

Process for preparing optically pure active compounds

The invention relates to a novel process for preparing (S)-pantoprazole using a chiral zirconium complex or a chiral hafnium complex.

Process for preparing (S)-pantoprazole

The invention relates to imidazopyridines of a certain formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric secretion-inhibiting properties.

Polysubstituted imidazopyridines as gastric secretion inhibitors

The invention relates to the dihydrate of the magnesium salt of pantoprazole.

Salt form of pantoprazole

Pyridylthio compounds for controlling helicobacter bacteria

Thiopyridines for use in the control of helicobacter bacteria

Piperazinothiopyridines for the control of Helicobacter bacteria

Substituted arylalkylthioalkylthiopyridines for use in the control of

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Constance, Germany

Bernhard Kohl