Hoffmann-la Roche Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Atnahs Pharma UK Limited

Bernhard Knipp

Tim Sattelkau

Bernd Junghans

Uwe Eiermann

Kleomenis Barlos

Thomas Albert Zeibig

Gerald Zieres

Martin Behringer

Bernhard Pfeil

Ralf Kucznierz

There is provided an improved method for the recovery of residual, unseparated &#x3b2;-acetylfuranoside from reaction mixtures remaining from an initial synthesis of acetylfuranoside, which is in particular usable on a large industrial scale, more particularly in the production of capecitabine.

Process for the recovery of beta acetylfuranoside

A process for the preparation of indoles, e.g. 1,2,3,9-tetrahydro-carbazol-4-one and derivatives thereof.

Process for the preparation of indoles

The present invention relates to a new polymorph crystal form of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1 1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula. 

Ibandronate polymorph

The present invention relates to a new crystalline polymorph of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formula 

The present invention relates to a recycling process for the preparation of solid phase bonded 2-chlorotrityl chloride (2-CTC resin) useful for solid phase peptide synthesis, wherein active chloride CTC resin is regenerated by reacting the spent resin with a chlorinating agent in organic solvent.

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Kuerten-Olpe, Germany

Bernhard Knipp