St. Jude Medical Puerto Rico LLC

Bernhard Kaeferlein

Troy White

Zachary J Tegels

Martha Escobar

Edward E Parsonage

Russell David Terwey

Timothy M McGlinch

Jason M Halac

Ali Hassan

James A McCrea

Zihan Lin

Catherine A Pipenhagen

Troy T White

A closure device operable to seal a vessel puncture and including a delivery member and a sealant material applicator. The delivery member is insertable through a tissue tract to the vessel puncture. The sealant material applicator is configured to supply a volume of sealant material to the delivery member and includes a housing, a plunger assembly, and at least one container. The housing includes at least first and second chambers, wherein the first chamber carries a first sealant component and the second chamber carries a second sealant component. The container is insertable into the first or second chamber and carries a third sealant component of the sealant material. The sealant material applicator creates flow communication between the container and at least one of the first and second chambers to mix the third sealant component with the first and second sealant components.

Sealant mixing containers for extra vascular bioadhesive delivery systems and methods

A sealant delivery device includes a delivery tube, a bioadhesive container, and an adapter. The delivery tube includes proximal and distal ends. The bioadhesive container holds a sealant activator and a sealant precursor separated from each other. The adapter is interposed between the delivery tube and the bioadhesive container. The adapter includes a first channel member that couples a first lumen of the delivery tube to the sealant activator, and a second channel member that couples the first lumen to the sealant precursor. The adapter provides separation of the sealant activator and the sealant precursor until a position distal of the bioadhesive container.

Systems and methods for sequential mixing of activator in bioadhesive delivery device

A bioadhesive mixing assembly includes first and second syringes and an adapter. The first syringe includes first and second chambers holding a first sealant component and an activator, respectively. The second syringe includes third and fourth chambers holding a second sealant component and one of an activator or a third sealant component, respectively. The adapter is mounted to the first syringe and includes first and second channels in flow communication with the first and second chambers, a first seal member providing sealed access to the first and second channels, first and second needles connected in flow communication with the third and fourth chambers, and a second seal member enclosing the first and second needles. Connecting the adapter to the second syringe punctures the first and second seal members with the first and second syringes to create flow communication between the first and third chambers and the second and fourth chambers.

Bioadhesive mixing and preparation systems and methods using two syringes

A suture locking device includes a carrier member, a locking assembly, a suture path, and an actuator assembly. The locking assembly includes a first locking member having an outer surface portion, and a second locking member having an inner surface portion. The suture path is receptive of a suture and defined at least partially through the first locking member, between the outer and inner surface portions, and at least partially through the carrier member. The actuator assembly is operable to move the first and second locking members together to lock the suture relative to the lock assembly.

Suture locking device and methods

A suture locking device includes a suture locking assembly, a suture cutting member, and an actuator assembly. The actuator assembly includes a first actuator operable longitudinally to lock the suture with the suture locking assembly, and a second actuator operable laterally to concurrently cut the suture with the suture cutting member and disconnect the suture locking assembly from the suture locking device.

A bioadhesive sealant storage and preparation system may comprise a plurality of containers and an adapter. The plurality of containers may comprise a first container having a first bioadhesive sealant component therein, and a second container having a second bioadhesive sealant component therein. The adapter may comprise a manifold comprising a plurality of channels formed therein, an inlet region sized and configured to receive the plurality of containers and facilitate fluid communication between each container of the plurality of containers and a respective channel of the plurality of channels, and an outlet region sized and configured to receive a syringe and provide fluid communication between the syringe and the plurality of channels.

Sealant storage, preparation, and delivery systems and related methods

A vascular closure system includes a body portion, an anchor, a suture carrying portion, and a plurality of needles. The body portion has a distal end surface. The anchor is positionable through a vessel puncture in a vessel wall of a vessel. The anchor defines a vessel contact surface, wherein withdrawal of the anchor captures a portion of the vessel wall between the vessel contact surface and the distal end surface. The suture carrying portion is positionable through the vessel puncture and carries at least one suture member. The plurality of needles extend through the portion of the vessel wall adjacent to the vessel puncture and are configured to connect to the at least one suture member. Withdrawal of the plurality of needles through the portion of the vessel wall positions the at least one suture member through the portion of the vessel wall.

Large bore closure device and methods

A tissue puncture closure device includes a delivery member, a handle assembly, and a sealant cartridge. The delivery member includes a sealant lumen and is insertable into a tissue puncture. The handle assembly is mounted to a proximal end of the delivery member and includes a cartridge chamber and a plunger member. The sealant cartridge is insertable into the cartridge chamber. The sealant cartridge has at least first and second sealant chambers carrying at least first and second sealant components, respectively. Operation of the handle assembly ejects the first and second sealant components into the sealant lumen for delivery to the tissue puncture.

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Champlin, MN, United States of America

Bernhard Kaeferlein