University of Minnesota

Diabetes-free Inc.

Bernhard J Hering

Christopher Burlak

Sabarinathan Ramachandran

Prashant Girinath

Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals.

Genetically modified cells, tissues, and organs for treating disease

The present disclosure is related to compositions and systems for inducing immune tolerance for transplanted cells, organ, or tissues in a transplant recipient. Also provided herein are methods of making and methods of administering tolerizing vaccines/regimen or preparatory regimens.

Transplant tolerance induction with carbodiimide treated tolerizing vaccine

The present disclosure is related to compositions comprising peptides that bind CD40 and methods of use in inhibiting interaction of CD40 and CD154 and inducing immunosuppression. Provided herein are methods of transplantation and methods of inhibiting donor specific immune response. Also provided herein are methods of treatment for autoimmune diseases, inflammatory diseases and cancer.

Growing community of inventors

Minnetonka, MN, United States of America

Bernhard J Hering