Basf Aktiengesellschaft

Basf Se Corporation

Basf Coatings Ag

Base Aktiengesellschaft

Bernhard Hauer

Michael Breuer

Rainer Stürmer

Thomas Friedrich

Wolfgang Ladner

Rolf Schmid

Uwe Pressler

Juergen Pleiss

Horst Ralf Staudenmaier

Dietmar Haering

Thomas Zelinski

Maria Keβeler

Uwe Meisenburg

Joachim Meyer

Ulrich Schwaneberg

Kurt Faber

Friedhelm Balkenhohl

Nina Schneider

Erich Beck

Hardo Siegel

Hartwig Schröder

Ralf Mattes

Helmut Schwab

Hans Wolfgang Höffken

Andreas Schmid

Bernd Bruchmann

Wolfgang Siegel

Dieter Hannu Boeckh

Heinz-Peter Rink

Maximilian Angel

Klaus Ditrich

Hansgeorg Ernst

Wolfgang Paulus

Thomas Pfeiffer

Stefan Becker

Frank Dietsche

Stephan Maurer

Eva Wagner

Volker Braig

Peter Fischer

Hans-Joachim Hähnle

Harald Larbig

Karl-Heinz Joost

Lidcay Herrera Taboada

Wolfgang Kroutil

Bryan Cooper

Tilo Habicher

Andreas Fechtenkoetter

Christoph Nubling

Alexander Göthlich

Dieter Jendrossek

Ursula Mueller

Demet Sirim

Cecilia Kvarnström Branneby

Dietmar Häring

Bettina Rosche

Jutta Schmitt

Markus Fischer

Qing-shan Li

Gabriele Siedenburg

Silvia Fadenrecht

Wolfgang Wohlleben

Marlene Buchebner

Brigitte Pohn

Dejana Drew

Christoph Nübling

Sabine Lutz-Wahl

Sabine Feichtenhofer

Clemens Stückler

Alexander Goethlich

Gerhard Klebe

Lysander Chrisstoffels

Ursula Schnell

Hartwig Schr&ouml;der

Andreas Pletsch

Melanie Bonnekessel

Melanie Hall

Steffen Maurer

Elmar Heinzle

Maria Kesseler

Rainer Stuermer

Bruno Bühler

David Leys

Dirk Barend Janssen

Till Bachmann

Wolf-Rüdiger Krahnert

Karl Hult

Jürgen Däuwel

Per Berglund

Gabrielle Siedenburg

André Mueller

Peter Trodler

Danni Liu

Tuck Seng Wong

Monika Müller

Dick B Janssen

Maja Majeric-Elenkov

Bettina M Nestl

Maeve O'Neil

The present invention relates to novel mutants with cyclase activity and use thereof in a method for biocatalytic cyclization of terpenes, such as in particular for the production of isopulegol by cyclization of citronellal; a method for the preparation of menthol and methods for the biocatalytic conversion of further compounds with structural motifs similar to terpene.

Method for the biocatalytic cyclization of terpenes and cyclase mutants employable therein

The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.

Method for the enzyme-catalysed hydrolysis of polyacrylic acid esters, and esterases used therefor

The invention relates to novel proteins having esterase activity, to mutants thereof, to nucleic acid sequences coding therefor, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.

Mutants of a pseudomonas glumae butynol esterase

The present invention relates to a process for the biocatalytic, enantioselective production of a &#x3b2;-amino acid precursor from an optionally substituted dihydrouracil using a hydantoinase and/or a dihydropyrimidinase, a process for producing a &#x3b2;-amino acid from said precursor, a hydantoinase and its use in said process for the biocatalytic production of a &#x3b2;-amino acid precursor or a &#x3b2;-amino acid, and a method for obtaining said hydantoinase.

Preparation of beta-amino acids

The present invention relates to a process for the production of a polyamine involving the use of enzymes; in particular to a process performed in aqueous environment; to the polyamines produced by said method; as well as the use of said polyamines for manufacturing paper, for immobilizing enzymes, or for preparing pharmaceutical or cosmetical compositions. The invention also relates to a novel method for in situ regeneration of cofactors NAD(P).

Process for the production of polyamines

The present invention relates to a method for the enzymatic decarboxylation of malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus. The present invention also relates to novel enzymes with a decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said decarboxylase activity.

Malonate decarboxylases for industrial applications

Process for producing optically active 3-aminocarboxylic acid ester compounds of general Formula I, and the ammonium salts thereof, in which in which Rand Rhave the meanings given above and Rstands for hydrogen, alkyl, cycloalkyl or aryl, is submitted to an enantioselective deacylation by adding a polypeptide according to claim

Amidase and use thereof for producing 3-aminocarboxylic acid esters

The present invention relates to methods for expressing nucleic acid sequences in prokaryotic host cells, where at least one DNA construct which is capable of episomal replication in a host cell and which comprises a nucleic acid sequence to be expressed under the transcriptional control of an L-rhamnose-inducible promoter, where the promoter is heterologous with regard to the nucleic acid sequence, is introduced into the host cell and the expression of he nucleic acid sequence is induced by addition of L-rhamnose, wherein the prokaryotic host cell is at least deficient with regard to an L-rhamnose isomerase.

L-rhamnose-inducible expression systems

The invention relates to a method for preserving and/or storing microorganisms which exhibit at least one nitrile hydratase or nitrilase enzyme activity, with the preservation and/or storage being effected in an aqueous medium which comprises at least one aldehyde, with the total aldehyde concentration being in a range from 0.1 to 100 mM/l.

Methods for preserving and/or storing cells having a nitrilase or nitrile hydratase activity

The invention relates to a process for the biocatalytic production of ambroxan by means of a polypeptide with the activity of a homofarnesol-ambroxan cyclase, which are a novel class of enzymes.

Biocatalytic production of ambroxan

The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived fromlipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of a mutated triacylglycerol lipase in a method of preparing mono-acylated polyols. The invention also provides novel mutants, coding sequences thereof, and recombinant microorganisms carrying said coding sequences.

Enzymatically catalyzed method of preparing mono-acylated polyols

A process for the enzymatic reduction of an enoate (1) wherein the C&#x2550;C bond of the enoate (1) is stereoselectively hydrogenated in the presence of an enoate-reductase and an oxidizable co-substrate (2) in a system which is free of NAD(P)H, in which A is a ketone radical (&#x2014;CRO), an aldehyde radical (&#x2014;CHO), a carboxyl radical (&#x2014;COOR), with R&#x2550;H or optionally substituted C-C-alkyl radical, R, Rand Rare independently of one another H, &#x2014;O&#x2014;C-C-alkyl, &#x2014;O&#x2014;W with W=a hydroxyl protecting group, C-C-alkyl, which can be substituted, C-C-alkenyl, carboxyl, or an optionally substituted carbo- or heterocyclic, aromatic or nonaromatic radical, or one of R, Rand Ris a &#x2014;OH radical, or Ris linked to Rso as to become part of a 4-8-membered cycle, or Ris linked to R so as to become part of a 4-8-membered cycle, with the proviso that R, Rand Rmay not be identical.

Process for the enzymatic reduction of enoates

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Fuβgönheim, Germany

Bernhard Hauer