Hoffmann-La Roche Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Bernhard Goller

Matthias Rueth

Petra Rueger

Guy Georges

Anja Limberg

Klaus-Peter Kuenkele

Frederick Arthur Brookfield

Walter-Gunar Friebe

Stefan Scheiblich

Edward Andrew Boyd

Birgit Bossenmaier

Wolfgang Von Der Saal

Hans-Willi Krell

Ulrike Reiff

Georg Tiefenthaler

Edgar Voss

Stefan Weigand

Manfred Kubbies

Thomas Friess

Claudio Bordignon

Justin Warne

Christine Schuell

Ruediger Rueger

Aude Lemarchand

Georges Guy

Sabine Huensch

The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

Aminopyrazole derivatives

The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

Tricycles, their manufacture and use as pharmaceutical agents

Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

Phthalazinone derivatives

The present invention 1 includes compounds of formula (I), and their pharmaceutically acceptable salts. These compounds are useful in the control or prevention of cancer.

Oxazole derivatives

A method for the simultaneous determination of cell proliferation inhibition activity and cell toxicity (induction of cell death) of a substance using a proliferating mammalian cell sample as a test system.

Simultaneous determination of cell proliferation inhibition activity and toxicity

A titer of retroviral vectors of at least about 10 colony-forming units/ml cell culture supernatants is obtained using an amphotropic retroviral packaging cell line which contains functional gag, pol and env genes integrated into the genome in which the expression of the genes gag and pol is regulated independently of the expression of the env genes, wherein the genome of the said cell line contains one or two functionally active env genes.

Amphotropic retrovirus packaging cell line, process for its production and use thereof

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Penzberg, Germany

Bernhard Goller