G.d. Searle & Company

Novartis Ag

Pharmacia Corporation

Pharmacia Corporation (of Pfizer, Inc.)

Novartis Pharma Gmbh

Bernhard Erb

John S Ng

Yuen-Lung L Sing

Leo J Letendre

Joseph J Wieczorek

Mark John Pozzo

Edward E Yonan

Chin Liu

Jon P Lawson

Dennis K Anderson

Sastry A Kunda

Ping T Wang

Julio A Baez

Fortunato Vanzanella

Gennaro Mucciariello

Richard M Weier

Robin Alec Fairhurst

Philipp Lustenberger

Jianguang Zhou

Arnaud Grandeury

Thomas Ullrich

Nicola Tufilli

Shinji Hatakeyama

Thomas R Kowar

Bernd Ulrich Riebesehl

Isabelle Sylvie Gallou

Magdalena Koziczak-Holbro

Xiang Wu

Jun Cao

Xinzhong Lai

Christoph Krell

Mahavir Prashad

Murat Acemoglu

Wen-Chung Shieh

Bernhard Wietfeld

Christoph Max Krell

Mark Meisenbach

Werner Heinz Pachinger

Stephan Abel

Walter Prikoszovich

Song Xue

Florian Karl Kleinbeck

Joseph Sclafani

Florian Karl Kleinbeck-Riniker

Werner Pachinger

Bernd Riebesehl

The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

Benzothiazolone compound

Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.

Synthesis of 2-carboxamide cycloamino urea derivatives

Provided herein are processes useful for the preparation of 2-carboxamide cycloamino urea derivatives of formula (X), and useful intermediates therefore, at internal temperatures such as less than about &#x2212;5&#xb0; C. to about &#x2212;15&#xb0; C. and using solvents such as tetrahydrofuran, bases such as amines, and the like.

The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II): 

Process for the synthesis of organic compounds

The present invention relates to processes for preparing peptides and to intermediates involved in such processes, e.g. a process for preparing a compound of formula VIII wherein Rand Rare as defined herein.

Process for the synthesis of peptides containing a 4-hydroxy-proline substructure

Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.

Keto-substituted steroid compounds

Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.

Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein:

Process for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein: &#x2014;A&#x2014;A&#x2014;, &#x2014;B&#x2014;B&#x2014;, R, R, Rand Rare as defined in the specification.

Processes for the preparation of 4,5-dihydro-5,7-lactone steroid compounds are provided.

Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein

Growing community of inventors

Gipf-Oberfrick, Switzerland

Bernhard Erb