Boehringer Ingelheim Gmbh

Dr. Karl Thomae Gmbh

Boehringer Ingelheim Pharma Kg

Karl Thomae Gmbh

Dr. Karl Thomae Gesellschaft MIT Beschrankter Haftung

Bernhard Eisele

Rudolf Hurnaus

Michael Mark

Roland Maier

Wolfgang Grell

Robert Sauter

Gerhart Griss

Nikolaus Kaubisch

Eckhard Rupprecht

Gerhard Hallermayer

Ralph-Michael Budzinski

Peter Muller

Eberhard Woitun

Matyas Leitold

Peter Baruch Mueller

Joachim Kahling

Gebhard Adelgoss

Gebhard Schilcher

Leo Thomas

Walter Haarmann

Rudolph Hurnaus

Urethanes, thio and dithio analogues and their use as inhibitors of cholesterol biosynthesis

Urethanes derived from azacycloalkanes, the thio and dithio analogues thereof and their use as cholesterol biosynthesis inhibitors

Benzothiazoles and benzoxazoles, drugs containing them, their use and

The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula ##STR1## (wherein n, m, p, A, W.sup.1, W.sup.2, X, Y, and R.sup.1 to R.sup.11 are as defined in claim 1) and the isomers, isomer mixtures and salts thereof, which have useful properties, in particular an inhibitory effect on cholesterol biosynthesis.

Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their

The invention relates to N,N-disubstituted arylcycloalkylamines of general formula ##STR1## wherein n, m, A, X and R.sup.1 to R.sup.7 are defined as in claim 1, the isomers, isomer mixtures and salts thereof, which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis.

N,N-disubstituted arylcycloalkylamines, the salts thereof,

There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula Ia as well as the compounds of Formula I possess blood-sugar lowering properties.

Carboxylic acid amides and pharmaceutical compositions containing them

Compounds of the formula ##STR1## wherein n and m are each 1, 2 or 3, and the sum of n+m is 4;

Azepine derivatives and their anti-thrombotic compositions and methods

This invention relates to novel indole derivatives of formula ##STR1## and the non-toxic, pharmacologically acceptable salts thereof. These compounds exhibit desirable pharmacological properties, especially lipid-level lowering and anti-atherosclerotic activity. The compounds of the invention may be prepared by, for example, alkylation of a corresponding hydroxy indole.

2[3-(4-Chlorophenyl)-1,2-dimethyl-1H-indol-5-yloxy]-2-methyl propanoic

Compounds of the formula ##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms,

Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their

Biphenyloxy derivatives and antihyperlipidemic use

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Biberach, Germany

Bernhard Eisele