Sartorius Stedim Biotech Gmbh

Bernhard Diel

Maik Sommer

Thomas Loewe

Sebastian Handt

Thomas Friese

Andre Dell

André Grebe

Andreas Klemm

Matthias Hielscher

Alexandre Espachs

Mandar Dixit

André Dell

Andreas Migge

Embodiments relate to a bioprocessing system having a main line for conduction of a main flow of a liquid medium, having a main flow pump and having a system part connected to the main line. The bioprocessing system comprises a powder transfer system and a feed line which is connected to the powder transfer system and which opens into the main line and which comprises a return flow preventer for prevention of a return flow of liquid medium, the powder transfer system feeds the additive into the feed line in powder form and drives it toward the feed point by means of a pressurized transport gas and at least some of the fed additive is input into the liquid medium within the main line downstream of the feed point before the liquid medium enriched with the additive passes through or reaches the system part connected to the main line.

Bioprocessing installation

The invention relates to an apparatusfor storing and/or processing at least one medium, in particular a bioprocessing device, comprising at least one disposable container, which is designed to accommodate at least some of the at least one medium, and at least one overpressure protection means, which is fluid-connected to the at least one disposable container. The at least one overpressure protection means is designed, when triggered, to conduct at least some of the at least one mediuminto an apparatus region′ in front of the overpressure protection meansin relation to a flow direction F, in particular into the at least one disposable containerand/or into at least one further, second container

Overpressure protection means

A single-use filtration device including a plurality of single-use filter capsules connected with each other by rigid lines, of which at least a part is firmly mounted in a raster universally specified by a holder. The filter capsules, in particular as regards the type of filter, type of construction and/or size, and/or the connections of the filter capsules, are preconfigured for a desired filtration process.

Preconfigured single-use filtration device

A method of filtering a large volume of a medium using a pre-sterilizable, at least partially automated single-use filtration device which includes an unfiltrate inlet, a filtrate outlet, a main line running between the unfiltrate inlet and the filtrate outlet, filter elements arranged in the main line, a venting line and sensors for detecting specific process parameters and regulating means for adjusting specific process parameters, wherein the sensors and regulating means are connected to an external monitoring and control system which is adapted for evaluating and processing sensor data and for piloting the regulating means based on one or more control algorithms, comprises the following process steps: a) filling the single-use filtration device with medium with low flow; b) venting the single-use filtration device through the venting line; c) closing the venting line; d) rinsing the single-use filtration device, in particular the filter elements; e) filtering the medium by means of the filter elements; f) re-rinsing with high flow; and g) closing the main line; wherein the process steps f) and g) are optional.

Method for filtering a large volume of a medium with a pre-sterilisable, at least semi-automated one-way filtration device

An automated single-use filtration device, in particular for large-volume filtration processes, comprises an unfiltrate inlet, one or more filter elements, a filtrate outlet and sensors for detecting specific process parameters and regulating mechanisms for adjusting specific process parameters. The sensors and regulating mechanisms are connected to an external monitoring and control system, which is adapted for evaluating and processing sensor data and for piloting the regulating mechanisms based on one or more control algorithms.

Automated single-use filtering apparatus, and method for controlling an automated single-use filtering apparatus

A device () is provided for ventilation and integrity testing of a filter unit () that can be supplied with pressure. The filter unit () has a filter element () arranged in a housing () between an inlet () and an outlet (). The housing () can be ventilated by an air filter () connected to the housing interior (). A filter valve () is arranged upstream of the air filter () facing the housing interior () and connects the air filter () to the housing interior (). The air filter () can be connected on its side facing away from the housing interior () to a test line () for supplying pressure. An inlet valve () is arranged upstream of the inlet () and connects an inlet line () to the housing interior ().

Device for ventilation and integrity setting

The invention relates to a system and a method for cell separation via a filter, with a powder bag which can be arranged in a recirculation circuit and is partly filled with a pulverulent filter aid and to which a cell solution containing the cells to be separated can be delivered from a bioreactor via a pump arranged in the recirculation circuit, the bioreactor, which has an agitator, being arranged in the recirculation circuit, and, when the recirculation circuit is interrupted, the bioreactor being connectable to the filter.

System and method for cell separation

The invention relates to a valve device and to a method for transferring a transfer medium, said valve device and method having an inflow, an outflow and two valve disks which are arranged one behind another in the direction of flow and are pivotable about a common rotational axis for opening and closing the lumen which surrounds them, wherein the inflow and the outflow are formed by two housing sections which are lockable together, the ends of which facing one another receive in each case a valve disk with a fixedly connected half-shaft, wherein, with the housing sections in the locked state, the two half-shafts form one common shaft which is pivotable about the rotational axis and the valve disks abut closely against one another, and wherein, with the housing sections in the non-locked state, the valve disks in each case close the lumen of the housing section receiving them.

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Dransfeld, Germany

Bernhard Diel