Biochemie Gesellschaft M.b.h

Sandoz Gmbh

Bernhard C Prager

Johannes Ludescher

Siegfried Wolf

Hubert Sturm

Ingolf Macher

Werner Veit

Heinrich Thaler

Johann Danklmaier

Peter Punk

Karl Wessely

The invention relates to a new process for the depletion of 7-amino-3-&lsqb;(E)-1-propen-1-yl&rsqb;-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-&lsqb;(Z)-1-propen-1-yl&rsqb;-3-cephem-4-carboxylic acid and 7-amino-3-&lsqb;(E)-1-propen-1-yl&rsqb;-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-&lsqb;(z/E)-1-propen-1-yl&rsqb;-3-cephem-4-carboxylic acid or by adsorption chromatography.

Process for the purification of a 3-cephem-4-carboxylic acid derivative

The invention relates to a new process for the depletion of 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-[(Z)-1-propen-1-yl]-3-cephem-4-carboxylic acid and 7-amino-3-[(E)-1-propen-1-yl]-3-cephem-4-carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-[(Z/E)-1-propen-1-yl]-3-cephem-4-carboxylic acid or by adsorption chromatography.

The invention relates to a new process for the depletion of 7-amino-3-�(E)-1-propen-1-yl!-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-�(Z)-1-propen-1-yl!-3-cephem-4-carboxylic acid and 7-amino-3-�(E)-1-propen-1-yl!-3-cephem-4 carboxylic acid, by means of the crystalline hydrochloride or a metal or amine salt of 7-amino-3-�(Z/E)-1-propen-1-yl!-3-cephem-4-carboxylic acid or by adsorption chromatography.

The invention provides an improved process for the production of 7-amino-3-alkoxymethlycephem-4-carboxyl acid derivatives.

Process for the production of 7-ACA derivatives

The invention relates to a new process for the production of the disodium salt hemiheptahydrate of ceftriaxone by reacting 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio] methyl}-3-cephem-4-carboxylic acid with 2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetic acid-(2-benzthiazolyl)thiolester in the presence of a base, characterized in that the reaction and the crystallization of the disodium salt hemiheptahydrate of ceftriaxone are carried out in aqueous acetone.

Process for the synthesis of the disodium salt hemiheptahydrate of

The invention relates to new stable, crystalline forms of the t-butylester of ceftazidime of formula ##STR1## and the production thereof.

Stable, crystalline form of a cephalosporin intermediate product

The invention provides crystallilne (6R, 7R)-7-[[2 ( 2-Amino-4-thiazolyl)-(Z)-2-(1-diphenylmethoxycarbonyl-1-methylethoxy)imino ]acetamido]-3-(1--pyridiniummethyl)-3-cephem-4-carboxylate and a process for its production.

Crystalline cephalosporin derivative

New process for the production of the pentahydrate of ceftazidime of formula ##STR1## characterized in that the ester group of the compound of formula ##STR2## or an acid addition salt thereof, is cleaved by the sole use of aqueous hydrochloric acid, and the resulting ceftazidime is either crystallized directly from the reaction mixture as the pentahydrate by adding a base, or first of all the dihydrochloride of the ceftazidime is isolated by adding acetone and/or ethanol or another anti-solvent which is miscible with water, and this is converted into the pentahydrate by known methods.

Process for the production of cephalosporin derivatives

The invention provides crystalline (6R, 7R)-7-[[2-(2-Amino-4-thiazolyl)-(Z)-2-(1-diphenylmethoxycarbonyl-1-methyle thoxy)imino ]acetamido]-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate and a process for its production.

Method for preparing crystalline cephalosporin derivative

De-acylation of Penicillins and Cephalosporins to obtain the corresponding 6-aminopenicillanic acid or 7-aminocephalosporanic acid by the imino halide/imino ether process using long chain bases.

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Worgl, Austria

Bernhard C Prager