Optiscan Biomedical Corporation

Woolsthorpe Technologies

Optiscan Limited

Cardiac Profiles, Inc.

Plensat LLC

Biotrack, LLC

Daedalus I , L.l.c.

Bernhard B. Sterling

Kenneth G. Witte

W. Dale Hall

Peng Zheng

Mark Wechsler

Richard Keenan

Bernhard B Sterling

James Roswell Braig

Daniel S Goldberger

Peter Rule

Charles E Kramer

Jennifer H Gable

Philip C Hartstein

Arthur Melvin Shulenberger

Richard A King

Kenneth I Li

Rick P Trebino

Julian M Cortella

Casper W Barnes

Robert D Gaffney

Richard L Keenan

Kenneth G Witte

W Dale Hall

David J Correia

Alexander K Mills

Joan C Godfrey

Gregory I Voss

David N Callicoat

Mark D Agostino

James M Perry

Rankin A Clinton, Iii

Rick Trembino

Andrew R Lawrence

Martin J Fennell

Robert Stone

Roger O Herrera

Kamrava Azizi

Ken Li

Jeffrey Sugarman

Heidi M Smith

Rogelio O Herrera

Kumar Subramanian

Fred Voss

Phillip C Hartstein

Marina Saltman

David C Klonoff

Ken G Witte

Mike A Munrow

David Klonoff

Jane J Sheill

Methods, associated algorithms, and systems for determining cardiac and/or cardiovascular performance from three measurements on a subject are presented, where two of the measurements are provided by plethysmographs and one measurement is provided by an electrocardiogram. The two plethysmographs are placed different distances from the subject's heart. Certain embodiments use the three measurements to calculate intermediate variables of a left ventricular ejection time and a pre-ejection period.

Method and system for determining cardiac performance

A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Analyte monitoring systems and methods

A method for determining a cardiac function, comprising (i) determining base anatomical characteristics associated with the subject, (ii) determining pulse delay to a first body site (PD) and a second body site (PD) as a function of the anatomical characteristics, wherein the distance via the arterial tree from the aortic valve to the first body site (PD) is different than the arterial tree distance from the aortic valve to the second body site (PD), (iii) determining pulse wave velocity between the first body site and the second body site (PWV), (iv) determining pulse wave velocity between the aortic valve and the first body site (PWV) as a function of PWV, and the anatomical characteristics; and (v) determining the pre-ejection period (PEP) as a function of PDand PWV.

Method for determining a cardiac function

A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

Method and apparatus for determining an analyte concentration in a sample having interferents

In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.

System and method for determining a treatment dose for a patient

An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

Analyte detection system for multiple analytes

In vitro determination of analyte levels within body fluids

The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

Method and system for treatment of eating disorders

In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 400 microliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.

Analyte detection system with reduced sample volume

In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.

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Danville, CA, United States of America

Bernhard B Sterling