Sanofi-a Ventis Deutschland Gmbh

Hoechst Aktiengesellschaft

Berndt Kulitzscher

Wolfgang Holla

Thomas Stuedemann

Christoph Tappertzhofen

Wolfgang Laux

Robert J H Scheffer

Rolf-Ludwig Hoerlein

Gerhard Beck

Frank Zocher

Bernhard Kammermeier

Stephane Mutti

Bernd Junker

Andreas Burgard

Jochen Hachtel

Christophe Salagnad

Rolf Hoerlein

Jurgen Michalowsky

Claus-Jügen Maier

Stéphane Mutti

The invention is related to a process for preparing compounds of the formula IV by means of conversion of aromatic aldehydes of the formula I using &#x3b1;-ketoximes of the formula II via N-oxides of the formula III to halomethyloxazoles of the formula IV, wherein R, R, R, R, R, R, R, R, X, X, X, o, n1 and n2 are as defined herein.

Method for the production of oxazoles by condensing aromatic aldehydes with &#x3b1;-ketoximes to N-oxides and then reacting the same with activated acid derivatives

The invention relates generally to a process for preparing diarylcycloalkyl derivatives of the formula (I). wherein the respective R-group substituents are defined herein. These compounds of formula (I) are activators for peroxisome proliferator-activated receptors (PPAR activators) which are useful in the therapeutic treatment of a number of diseases and disorders of the central nervous system such as multiple sclerosis, Parkinson's Disease, psychiatric disorders and the like. The present invention is a novel process for preparing PPAR activators of the formula (I) which do not have the disadvantages of the processes known in the prior art. In particular, a process is provided with which the PPAR activators of formula (I) can be prepared in a suitable enantiomeric excess, i.e. high enantioselectivity, without the need for subsequent chiral chromatography.

Method for the production of diarylcycloalkyl derivatives

The present invention is comprised of improved methods in the preparation of oxazoles which results in higher yields with less impurities and contaminants. Oxazoles constitute valuable intermediates in the synthesis of pharmaceutically active substances such as, for example peroxisome proliferator activated receptor (PPAR) agonists which are pharmaceutical actives which can have a positive influence on both lipid and glucose metabolism.

Method for the preparation of oxazoles by condensing aromatic aldehydes with &#x3b1;-ketoximes to form n-oxides and reacting same with activated acid derivatives

The present invention relates to a process for the preparation of chiral, nonracemic compounds of the formula I ##STR1## in which R.sup.1 and R.sup.2 have the meanings indicated in claim 1 and which are useful intermediates for the preparation of pharmaceutical active compounds in which, for resolution, a salt is formed from the racemic compound of the formula I and a chiral, nonracemic amino compound. It furthermore relates to compounds of the formula I and esters thereof.

Process for the preparation of chiral, nonracemic

In the device for the damping of pumps with intermittent delivery, a feed line (2) and a discharge line (3) for the medium to be delivered protrude into a slender tube (1), closed on both sides. The lines (2, 3) are led into the tube through one of the closed ends of the tube (1). In this arrangement, at least the outflow opening (8) for the discharge line (3) is arranged in the vicinity of the other closed end (9) of the tube.

Device for the damping of pumps with intermittent delivery

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Esselbach, Germany

Berndt Kulitzscher