Bayer Aktiengesellschaft

Bernd Sennhenn

Rudolf Schohe-Loop

Dietrich Gehrmann

Werner Kroll

Horst Weber

Maria-Luisa Rodriguez

Ariane Firus

Martin Kramer

Ferdinand Rombout

A drying unit for removing solvent from moist material, and a method for drying moist material with the drying unit. The unit comprises at least one drying chamber () having at least one stand plate () for holding vessels (), which are filled with moist material, or flat layers of moist material, the drying chamber () being connected to a condenser () via a vapor passage (), in which sublimed solvent can be separated out, the stand plates () being connected to a temperature-controlled heating/cooling circuit, the chamber () having heating/cooling plates () or (') which are connected to a second heat-transfer circuit, wherein the heating/cooling plates () or (&#x2032;) are substantially thermally isolated from the chamber wall ().

Freeze-drying apparatus

The invention relates to a lyophilization method which comprises the following steps: reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation; reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in a frozen solvent; and sublimation of the frozen solvent by means of reduced pressure.

Lyopohilization method

The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration of repinotan or its metabolites in body fluids, and also new pharmaceutical compositions containing repinotan or a physiologically acceptable salt of repinotan, and processes for their preparation.

Repinotan kit

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Leverkusen, Germany

Bernd Sennhenn