Schering Aktiengesellschaft

Bayer Schering Pharma Ag

Shering Ag

Bernd Radüchel

Johannes Platzek

Thomas Frenzel

Hanns-Joachim Weinmann

Heribert Schmitt-Willich

Ulrich Niedballa

Wolfgang Ebert

Bernd Misselwitz

Wolfgang Schlecker

Andreas Mühler

Werner Skuballa

William J Guilford

Monica J Kochanny

Detlev Sülzle

Hans Bauer

Heiko Schirmer

Wheeseong Lee

Daryl Faulds

Günther Michl

This invention is directed to compounds of formula (I): where A, B, D, E, m, and R-Rare as described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, clathrates, or prodrugs thereof, which compounds are useful in treating respiratory diseases associated with influenza A viruses, such as for example H5N1 and its mutations. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.

5-cyano-prostacyclin derivatives as agents for the treatment of influenza a viral infection

The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.

Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis

Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging.

Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes

The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.

Macrocyclic metal complexes and their use for the production of conjugates with biomolecules

Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.

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Berlin, Germany

Bernd Radüchel