Fresenius Ag

Fresenius Medical Care Deutschland Gmbh

Bernd Nederlof

Massimo Earl Fini

Franz Kugelmann

Ciro Tetta

Michael Paul

Marco Caronna

Thomas Wild

Paul Hengster

Micaela Yakubovich

Raimund Margreiter

A reactor has a reactor unit with a first chamber and a second chamber, with the first chamber being formed by the interior of a housing and the second chamber being formed by the interior of a plurality of hollow fibers arranged in the housing. The hollow fibers are arranged in the housing such that their density in at least one region of the first chamber does not exceed 10 fibers/mm, based on the cross-sectional area of the first chamber. The reactor unit can include two casting compounds, in which a portion of the hollow fibers are embedded and between which another portion of the hollow fibers extends. The length of at least some or all of the hollow fibers is at least 0.5% greater than the distance of the casting compounds.

Reactor and reactor unit with hollow fibers

A hemo(dia)filtration apparatus (10) is described comprising a dialyzer (12) and two sterile filters (38) and (60). The first chambers (42) and (64) of both sterile filters (38) and (60) may be switched at least intermittently during flow through, thereby flushing out membranes (40) and (62) of both sterile filters (38) and (60) and effectively preventing an accumulation of germs and pyrogens. This prevents an increase in the transmembrane pressure (TMP), which reduces the likelihood of a rupture, thereby ensuring sterility of the dialyzer fluid and improving the operating safety of the hemodiafiltration apparatus (10).

Hemo(Dia)filtration apparatus

Described is a hemo(dia)filtration apparatus (10) with two blood filters (60) and (12) connected in series and a sterile filter (38) connected upstream thereof. The first chambers (64) and (14) and the second chambers (68) and (16) of both blood filters (60) and (12) are connected to one another, respectively, by connecting lines (72) and (74). A means (76) is arranged in one of the connecting lines (72) and (74), which generates a positive transmembrane pressure in the direction of the blood path in one of the blood filters (60, 12) and a negative transmembrane pressure in the direction of the blood path (80) in the other blood filter (12, 60). This eliminates a costly substituate line with additional devices arranged therein, since the dialyzer fluid is passed as a substituate solution through the membrane of the one blood filter directly into the blood. Furthermore, with the use of suitable devices it is possible to precisely determine and individually adjust the filtrate and substituate flows.

Hemo(dia)filtration apparatus and filtrate flow regulator

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St. Wendel, Germany

Bernd Nederlof