Dsm IP Assets B.v.

Provexis Natural Products Limited

Bernd Mussler

Daniel Raederstorff

Jaroslav A Kralovec

Regina Goralczyk

Joseph Schwager

Goede Schueler

Ying Wang-Schmidt

Ann Fowler

Antoine De Saizieu

Szabolcs Peter

Weerasinghe M Indrasena

Nathalie Richard

Hubert Hug

The present invention relates to compositions comprising a water soluble tomato extract (WSTE) which may be used in maintaining cardiovascular health, lessening the risk of developing cardiovascular health problems, or reducing the likelihood of worsening an existing cardiovascular health problem in a subject exposed, or is at risk of exposure, to particulate air pollution.

Water soluble tomato extract protects against adverse effects of air pollution

The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver&#x2014;known as non-alcoholic fatty liver disease (NAFLD)&#x2014;and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.

Treatment for non-alcoholic fatty liver diseases

Use of DIM and/or its derivatives for prevention, treatment and/or delay of age-related hearing loss in mammals.

Use of 3,3'-diindolylmethane

The present invention refers to coumarin ethers of the formula (I), wherein Ris H, OH or (E)-3-methyl-but-2-enyl, Ris selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, Ris H, Rand RO together for the group &#x2014;O&#x2014;C(C(&#x2550;CH)CH)H&#x2014;CH&#x2014;O&#x2014; or the group &#x2014;C(H)&#x2550;C(H)&#x2014;C(CH)&#x2014;O&#x2014; or RO and Rtogether form the group &#x2014;O&#x2014;C(H)(C(CH)(H)&#x2014;O&#x2014;C(O)CH)&#x2014;CH&#x2014;, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.

Agents for preventing and treating disorders connected to impaired neurotransmission

Growing community of inventors

Kaiseraugst, Switzerland

Bernd Mussler