Hoffmann-la Roche Inc.

Bernd-Michael Loffler

Werner Neidhart

Henri Ramuz

Martine Clozel

Georges Hirth

Kaspar Burri

Marcel Muller

Volker Breu

Jean-Marie Cassal

Walter Fischli

Compounds of formula I ##STR1## wherein R.sup.1 signifies phenyl, substituted phenyl or heterocyclyl;

Aryl-  and hetaryl-sulfonamide derivatives, their preparation and their

Sulfonamides

Aryl- and hetaryl-sulfonamide derivatives, their preparation and their

Compounds of formula I: ##STR1## are disclosed. The compounds inhibit the binding of endothelin to its receptors.

Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin

Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.

Sulphonamides

The invention is concerned with novel sulphonamides and their use as medicaments. In particular, the invention is concerned with compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, lower-alkyl, lower-alkoxy, lower-alkylthio, halogen or trifluoromethyl;

Phenylsulfonylamide pyrimidine

The novel sulfonamides of formula I, ##STR1## in which the symbols R.sup.1 -R.sup.9, R.sup.a, R.sup.b, X, Y and n have the significance given in the description and salts thereof can be used for the treatment of circulatory disorders, especially hypertension, ischemia, vasopasms and angina pectoris.

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Oberrimsingen, Germany

Bernd-Michael Loffler