Asta Medica, Aktiengesellschaft

Bernd Kutscher

Jurgen Engel

Wolfgang Schumacher

Alfred Olbrich

Ulf Niemeyer

Gerhard Nossner

Gerhard Nssner

A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.

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Maintal, Germany

Bernd Kutscher