Gambro Lundia Ab

Baxter International Inc.

Baxter Healthcare Sa

Charité – Universitätsmedizin Berlin

Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Gambro Lundis Ab

Universitat Twente

Gambro Dialysatoren Gmbh

Rheinisch-westfälische Technische Universität Hochschule (rwth) Aachen

Bernd Krause

Markus Storr

Markus Hornung

Carina Zweigart

Joachim Loercher

Ying-Cheng Lo

Yuanpang Samuel Ding

Joseph V Ranalletta

Reinhold J Buck

Arnd Wochner

Mark Edward Pasmore

Grant Anthony Bomgaars

Michael Joseph Sadowski

Heinrich Behr

Philipp Herbst

Manuel Voigt

Adriana Boschetti-De-Fierro

Thomas Edward Dudar

Werner Beck

Anastasios Hristakos

Ralf Flieg

Markus Neubauer

Reinhold Deppisch

Hermann Goehl

Hermann Göhl

Johannes Geckeler

Mark Joseph Doty

William S Hurst

Hermann Josef Gohl

Matthias Wessling

Steffen Wagner

Helmut Hildwein

Ulrich Bauer

Herman Goehl

Steven C Jepson

Karl Hans Cazzini

Thomas Ertl

Marc Steven Minkus

Christine L Rebbeck

Jürgen Dannenmaier

Wolfgang Freudemann

Christof Beck

Michael Müller

Martin Rempfer

Hans-Georg Herz

Andrea Schnell

Christian Oehr

Bernd Hertzler

Rainer Blickle

Ralf Menda

Joseph Vincent Ranalletta

Jacob Daniel Rivett

Juergen Graf

Ralf Schindler

Daniel Zickler

Ferdinand Schweiger

Bjoern Hegner

Adriana Boschetti Castro

Reinhold Buck

Edmund Kurz

Heinrich Malthaner

Stefanie Votteler

David Luttropp

Helmut Geiger

Juergen Bereiter-Hahn

Patrick Baer

Cornelia Winz

Jan Swartjes

Stephan Aldinger

Christoph Beck

Christel Mohlenkamp

Hylke Sijbesma

Michael Hulko

Heiner Strahtmann

Oliver Amon

Alexander Gekeler

Arne Welzel

Sydney Jean Cope

Karl Heinz Klotz

David Filiberto Schuck

Szymon Dutczak

Simon Beiter

Manuela Klotz

Joerg Williardt

Colin Hutchison

Paul Cockwell

Silvia Koch

Michael Kather

Vivian Stefan Kurbel

Michael Alders

Ilka Rose

Verena Kieferle

Carina Kraft

William Spencer Hurst

Steven Clarence Jepson

The present invention relates to a continuous process for preparing permselective hollow fiber membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood which comprises a two-stage drying and tempering treatment of the hollow fiber membranes. According to a further aspect, the invention relates to a continuous process for drying permselective hollow fiber membranes on-line. The invention also relates to devices for on-line drying of permselective hollow fiber membranes.

On-line drying of hollow fiber membranes

The invention relates to a dispenser of a sealant for hemostasis comprising a container configured to receive a fibrinogen solution and an activation compartment being situated downstream of the container and comprising a functionalized support to which a coagulation factor, preferably thrombin, is immobilized, such that upon dispensing the fibrinogen solution it passes through the activation compartment, thereby generating and dispensing polymerizing fibrin as a sealant. The invention further relates to a support, exchangeable tip and a kit for the dispenser as well as to methods and uses of the dispenser or components thereof for dispensing a sealant to a desired site.

Device and method for the delivery of a thrombin activated fibrin sealant

Synthetic membranes for the removal, isolation, or purification of substances from a liquid. The membranes include at least one hydrophobic polymer and at least one hydrophilic polymer. 5-40 wt.-% of particles having an average particles size of between 0.1 and 15 μm are entrapped. The membrane has a wall thickness of below 150 μm. Methods for preparing the membranes in various geometries, and use of the membranes for the adsorption, isolation, and/or purification of substances from a liquid are explored.

Doped membranes

The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

Hemodialyzer for blood purification

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

Membrane for blood purification

A medical product includes a bladder, a filtration device, and a sterile product concentrate. The bladder has a perimeter seal and defining a sterile chamber. The filtration device includes a stem and a filter membrane disposed in line with the stem. The stem extends through the perimeter seal and has an inlet end accessible from outside of the perimeter seal and an outlet end in fluid communication with the sterile chamber. The filter membrane can have a nominal pore size in a range of approximately 0.1 μm to approximately 0.5 μm, wherein the filter membrane is shaped as a hollow fiber with a wall and pores residing in the wall of the fiber. The sterile product concentrate is disposed in the sterile chamber and adapted to be reconstituted by the introduction of a pharmaceutical fluid into the chamber through the filtration device.

Medical product including pre-filled product bag

A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.

Terminal sterilization filtration closed lyophilization in a container

A system for reconstituting and sterilizing a concentrate includes a mixing container, a filtration device, and a product bag. The a mixing container has an inlet port and outlet port in fluid communication with a mixing chamber disposed between the inlet port and the outlet port. The mixing chamber is adapted to contain a product concentrate. The filtration device has an inlet and an outlet, the inlet of the filtration device coupled to the outlet port of the mixing container. The filtration device includes a filter membrane with a nominal pore size in a range of approximately 0.1 &#x3bc;m to approximately 0.5 &#x3bc;m. The product bag has an inlet port coupled to the outlet of the filtration device, and has a bladder defining an empty sterile chamber for receiving sterilized and reconstituted product resulting from mixing a diluent with a product concentrate in the mixing chamber to obtain a mixture then introduced through the filtration device to obtain the reconstituted and sterilized product.

Dual container system for product reconstitution

A method of providing a plurality of filled product bags of sterile fluid includes positioning a bag assembly onto a filling machine. The bag assembly includes a tube, a filter assembly, bladders, and stems. A stem is attached to a bladder, forms a fluid passageway, fluidly connects to the tube, and provides fluid communication into the bladders. The method includes fluidly coupling an inlet of the filter assembly to a connection line in fluid communication with a fluid source, and filling the bag assembly with a fluid. Filling the bag assembly includes passing the fluid through the filter assembly, the fluid passageway, and into the bladder. The method includes sealing the fluid passageway at a location between the tube and the bladders. The method includes cutting the stem to form a partially filled product bag having the sealed passageway. The method includes performing an integrity test on the filter assembly.

Method and machine for producing sterile solution product bags

The invention relates to a membrane which can be used for cultivating adherent or suspension cells, in particular adherent cells, wherein said membrane allows for the adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma- or beta-rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. The invention further relates to a method for preparing said irradiated membrane which can be used for the cultivation of cells, in particular adherent cells, and to methods of using such a membrane for the cultivation of cells, in particular adherent cells.

Irradiated membrane for cell expansion

A sterile solution product bag includes sterilization grade filter integrated directly into the product bag such that microbial and particulate matter filtration can be performed using the filter directly at the point of fill. The filter can include a hollow fiber filter membrane contained in a stem connected to a bladder of the product bag.

Sterile solutions product bag

A syringe system includes a syringe and a filtration device connected to the syringe for sterilizing and introducing fluid into the syringe. The syringe includes a syringe barrel having a proximal end defining a barrel opening, a distal end defining a delivery opening, a bore extending between the proximal end and the distal end, and a stopper disposed in the bore of the syringe barrel. The filtration device has an inlet and an outlet coupled in fluid communication with the delivery opening at the distal end of the syringe barrel. The filtration device includes a stem and a filter membrane disposed in line with the stem. The filter membrane optionally has a plurality of pores each with a nominal pore size in a range of approximately 0.1 &#x3bc;m to approximately 0.5 &#x3bc;m such that a pharmaceutical fluid can be introduced as a sterilized pharmaceutical fluid into the bore of the syringe barrel by passing through the filtration device.

Medical syringe system with filtered filling port

The present disclosure relates to an artificial, extracorporeal system for supporting the function of the liver of a patient suffering from liver failure, which is characterized in that it comprises a first high-flux or high cut-off hollow fiber membrane dialyzer which is perfused on the lumen side with the patient's blood and wherein a buffered aqueous solution comprising human serum albumin is passed in a continuous flow through the filtrate space of said first dialyzer, a second hollow fiber membrane dialyzer which removes water-soluble substances from the dialysate of said first dialyzer, and a third, integrated hollow fiber membrane dialyzer which is perfused with the retentate of second hemodialyzer and which allows the passage of certain amounts of albumin over the membrane wall into the filtrate space which is populated with adsorbent material. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.

Liver support system devices and methods thereof

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Rangendingen, Germany

Bernd Krause