4sc Ag

Quonova, LLC

Bernd Kramer

Wael Saeb

Gabriel Garcia

Katharina Aulinger-Fuchs

Johan Leban

Andreas Wuzik

Aldo Ammendola

Astrid Gotschlich

Martin Lang

Udo Sinks

Johann Leban

Stefan Tasler

Stefano Pegoraro

Kristina Wolf

Roland Baumgartner

Rolf Krauss

Andrea Aschenbrenner

Katharina Aulinger Fuchs

Matthias Dormeyer

Jürgen Kraus

The present invention relates to a novel compounds that can be used as anti-inflammatory, immunomodulatory and antiproliferatory agents. In particular, the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehyrogenase (DHODH).

Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents

The present invention relates to the use of compounds of the general Formula (XIII): 

Modulation of pathogenicity

The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I),

The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.

Method of identifying inhibitors of DHODH

The present invention relates to novel compounds that can be used as antiinflammatory, immunomodulatory and antiproliferatory agents. In particular the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehydrogenase (DHODH).

The invention relates to new diphenylurea having the formula (I)or a salt thereof, where

Compounds for the treatment of protozoal diseases

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Aachen, Germany

Bernd Kramer