Cassella Aktiengesellschaft

Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Hoechst Marion Roussel

Cassella Aktiengessellschaft

Bernd Jablonka

Melitta Just

Gerhard Zoller

Wolfgang Konig

Jochen Knolle

Otmar Klingler

Gerhard Breipohl

Karl Schonafinger

Ursula Schindler

Rudi Beyerle

Hans-Ulrich Stilz

Jeffery Troke

Heinz-Werner Kleemann

Gary A Flynn

Hans Ulrich Stilz

Wolfgang Linz

Manfred Gerken

Bernhard Seuring

Barbara Ann Anderson

Werner Seiz

Wolfgang K Onig

This invention discloses and claims a series of mercaptoacetylamide derivatives of formula I. Also disclosed and claimed are pharmaceutical compositions incorporating these compounds and processes for preparing said compounds. The use of said compounds for inhibition of the enzymes angiotensin converting enzyme and neutral endopeptidase, and for the treatment of hypertension and congestive heart failure are also disclosed and claimed

Mercaptoacetylamide derivatives, a process for their preparation and their use

5-Membered ring heterocycle of the formula I,

Substituted 5-membered ring heterocycles comprising a bicyclic or tricyclic group their preparation and their use

Substituted 5-membered ring heterocycles, their preparation and their use

Urea derivatives, their preparation and use

Hydantoin derivatives of the formula I ##STR1## in which n is 3 or 4, R.sup.1 is alkyl or a radical of the formula R'--NH--C.dbd.N--R' with R' and R' being hydrogen or alkyl, and R.sup.2 is hydrogen, --NH--CO--NH.sub.2 and optionally substituted alkyl, and a process for the preparation thereof and the use thereof for inhibiting platelet aggregation, are described.

Hydantoin derivates

Substituted amino compounds, their preparation and their use as

Heterocycles, their preparation and their use

The present invention relates to compounds of the general formula I ##STR1## in which R, R.sup.1 to R.sup.4, r, Y, Z and W are defined as indicated in the description, a process for their preparation and their use as inhibitors of platelet aggregation, metastasis of carcinoma cells and osteoclast binding to the bone surfaces.

Imidazolidine derivatives

Phenylimidazolidine derivatives of the general formula I ##STR1## in which, for example, Y denotes --CH.sub.2 --CH.sub.2 --CO--

Phenylimidazolidine derivatives and their use

Aspartic acid derivatives of the formula ##STR1## in which X denotes, for example, ##STR2## and R denotes, for example, cyclohexylamino, have useful pharmacological properties.

Aspartic acid derivatives, and their use for inhibiting platelete

The present invention relates to 2,4-dioxoimidazolidine compounds of the formula I ##STR1## a process for their preparation and their use as inhibitors of platelet aggregation, metastasis of carcinoma cells and osteoclast binding to the bone surfaces.

2,4-dioxoimidazolidine compounds and compositions, and processes for

The invention relates to compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y have the meanings indicated in Claim 1, to processes for their preparation and their use as active pharmacological substances.

Hydantoin derivatives

The present invention relates to thienylacetic acid derivatives of the general formula I ##STR1## in which X denotes --O-- or --NH--;

Thienylacetic acid derivatives, process for the preparation thereof, the

The present invention relates to thienylpiperazines of the general formula I ##STR1## in which R.sup.1 denotes hydrogen or double-bonded oxygen and R.sup.2 denotes hydrogen or double-bonded oxygen, with R.sup.1 and R.sup.2 not both having the same meaning, as well as the pharmaceutically tolerated salts thereof, process for the preparation thereof, the use thereof, and pharmaceuticals containing these and the preparation thereof.

Thienylpiperazines, the use thereof and pharmaceuticals containing these

Growing community of inventors

Bad Soden, Germany

Bernd Jablonka