Roche Diabetes Care, Inc.

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Bernd Hiller

Herbert Harttig

Daniela Pfiffi

Ahmet Konya

Ewald Rieger

Herbert Fink

Christa Sternberger

Hans List

Joachim Hoenes

Carina Horn

Frank Deck

Rudolf Pachl

Volker Zimmer

Wolfgang Petrich

Oliver Kube

Hans-Juergen Kuhr

Wolfgang-Reinhold Knappe

Frederic Wehowski

Joerg Dreibholz

Otto Fuerst

Otto Gaa

Wolfgang Schwoebel

Josef Roeper

Werner Finke

Beate Koschorreck

Franz Wittmann

Ulrich Mueller

Alexander Kasejew

Luis David Bedon-Gomez

Maria Dambach

Volker Hullen

Christoph Grulke

Markus Siebenhaar

Wolfgang Schwöbel

Ursula Lehr

Volker HÜLLEN

Jörg Dreibholz

A method and an apparatus are described for the generation of microparticles containing an immobilized functional component, where the following measures are proposed:

Method and apparatus for generation of microparticles containing immobilized enzyme

A sensor device for determining the concentration of an analyte under in-vivo conditions that includes an electrode system having an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion from the exterior of the electrode system to the immobilized enzyme molecules. The diffusion barrier may include an aliphatic polyurethane. A process of manufacturing such a sensor device is also disclosed.

Sensor device for determining the concentration of an analyte under in-vivo conditions and process of manufacturing

A method for manufacturing a test element for detecting at least one analyte in a body fluid, a test element for detecting at least one analyte in a body fluid, a method for detecting at least one analyte in a body fluid, a system for detecting at least one analyte in a body fluid and a method for manufacturing a test element for detecting at least one analyte in a body fluid are disclosed. The method for manufacturing a test element for detecting at least one analyte in a body fluid comprises the following steps: wherein at least one hydrophilic material is applied in a manner that at least one surface section of the channel surface is covered with the hydrophilic material, wherein the surface section is adjacent to the test chemical.

Method for manufacturing a test element for detecting an analyte in a body fluid

Methods are disclosed for manufacture of test elements for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The methods include providing the base element, and mounting the cover element to the base element with an adhesive, wherein the adhesive contacts at least one test field of the cover element such that the adhesive is interposed between the test field and the base element and at least partially covers the test field. The test elements also include at least one fluid channel formed within the housing, where the the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The at least one test field has at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte.

Test elements for detecting at least one analyte in a body fluid, as well as methods of manufacturing the same

Test elements are disclosed for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The test elements also include at least one fluid channel formed within the housing, where the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The cover element includes at least one test field having at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte. In addition, the cover element is mounted to the base element via at least one adhesive that contacts the test field.

A method for producing an analytical tape, in particular a lancet tape, is proposed. The analytical tape is designed for being used in an analytical testing device with at least a sample-taking function. In the method, at least one supporting tape is provided in a continuous process. A plurality of lancet elements are successively applied directly to the supporting tape at at least one application point.

Optimized lancet tape

A puncturing system includes a carrier tape carrying multiple lancets and having position marks, a housing comprising a conveying facility for positioning the lancets and a housing opening, a puncturing drive for accelerating a lancet positioned in a usage position, a storage medium for storing distance values that depend on distances between the lancets of the carrier tape and position marks allocated to the respective lancets, a sensor for detecting position marks in a detection position through which the position marks proceed upon motion of the carrier tape, and a control unit that controls the conveying facility. To position a lancet in the usage position, the control unit stops the conveying facility upon the carrier tape moving a positioning distance. The length of the positioning distance depends on the distance between the lancet to be positioned and the detected position mark and is determined by the control unit.

Puncturing system, lancet reservoir system and manufacturing method, and method for positioning functional elements on carrier tape

Methods of producing an analysis spreading layer for absorbing a liquid to be analyzed, by: supplying a porous membrane having a bottom, a top and a thickness D, the size of the pores of the membrane increasing over its thickness D; cutting the membrane at a predefined distance, the spreading layer being a sublayer with a thickness d less than the starting thickness D, the pores of the spreading layer having a fluid connection to one another in such a manner that it is permeable to a liquid. The membrane surface is formed by removing a sublayer of the membrane being the liquid outlet side of the spreading layer. The mean size of the pores on the liquid outlet side is at least 1 &#x3bc;m.

Method for producing an analysis element spreading layer

Disclosed is a process for manufacturing packaged lancets. The steps of the process include providing a tape comprising a plurality of lancets comprising a lancet tip and a lancet body, enveloping at least the lancet tip with at least one foil, whereby the at least one foil forms a first and a second portion that overlap at least partly, and sealing the at least one foil with a laser beam at least at the edges of the first and second portion of the overlapping foil.

Process for manufacturing packaged lancets and device for analyzing body fluid

An aqueous control liquid is provided that contains glucose at a known concentration and cyclodextrin. A method is also provided that binds a wetting agent from a region of a test element that comes into contact with a sample. The method includes contacting the region with a control liquid that has a substance selected from the group of cyclodextrin derivatives and dispersed materials having a specific surface of 100 m /g to over 1000 m /g. A method for controlling the function of a measuring system having test strips and a measuring instrument for the determination of glucose in liquid samples is provided that includes contacting the test strip with a control liquid containing glucose at a known concentration and at least one substance selected from the group consisting of cyclodextrins and cyclodextrin derivatives and detecting a signal caused by the glucose contained in the control liquid.

Control liquid containing an adsorbent

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Lampertheim, Germany

Bernd Hiller