Ciba-geigy Corporation

Novartis Corporation

Bernd Groner

Norman Hardman

Winfried Stephan Wels

Markus Zwickl

Nancy E Hynes

Hiroshi Wakao

Fabrice Gouilleux

Ina-Maria Harweth

Ina-Maria Harwerth

The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacture of said recombinant antibodies and said monoclonal antibodies, hybridoma cells secreting said monoclonal antibodies, a method of manufacture of said hybridoma cells, DNA coding for the heavy chain variable domain, for the light chain variable domain and for the recombinant antibody, a method of manufacture of said DNA, hybrid vectors suitable for expression of said DNA, host cells transformed with said DNA, and the use of said recombinant antibodies and said monoclonal antibodies in the diagnosis and treatment of tumors.

Recombinant antibodies specific for a growth factor receptor

The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacturing those recombinant and monoclonal antibodies, hybridoma cells secreting those monoclonal antibodies, a method of manufacturing those hybridoma cells, DNAs encoding the heavy and light chain variable domains and the recombinant antibody, a method of manufacturing that DNA, hybrid vectors suitable for the expression of that DNA, host cells transformed with that DNA, and processes of using those recombinant and monoclonal antibodies in the diagnosis and treatment of tumors.

The present invention discloses isolated nucleic acids encoding MGF and recombinant proteins encoded thereby. In addition to being useful for the production of recombinant MGF, these nucleic acids are also useful as probes. In a further aspect of the invention, transfected host cells, particularly eukaryotic cells, containing and expressing such nucleic acids are provided. Furthermore, the present invention relates to methods for using such MGF proteins to identify and characterize compounds which affect the intracellular signal transduction of a lactogenic hormone.

Cytokine regulated transcription factor

Growing community of inventors

Basel, Switzerland

Bernd Groner